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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effects of renal dysfunction on the pharmacokinetics of loracarbef.

Loracarbef, the first carbacephem antibiotic to undergo clinical development, is excreted primarily unchanged in the urine (> 90%). Data analyzed from subjects with various degrees of renal dysfunction who were given single oral doses of loracarbef indicated a linear relationship between creatinine clearance (CLCR) and plasma clearance [ CLP (L/hr) = 0.106.CLCR (ml/min/1.73 m2)]. The mean area under the plasma concentration-time curve in normal subjects and in patients with severe renal insufficiency (no dialysis/receiving dialysis) was 32 and 1085, respectively. Therefore, for individuals with moderate renal insufficiency (CLCR, 10 to 49 ml/min/1.73 m2), the dose should be halved or the dosing interval doubled; patients with severe renal insufficiency who are not receiving dialysis should be treated with the normal dose given once every 3 to 5 days. Loracarbef is readily cleared from plasma by hemodialysis; dosing should be repeated after a hemodialysis treatment.[1]


  1. Effects of renal dysfunction on the pharmacokinetics of loracarbef. Therasse, D.G., Farlow, D.S., Davidson, R.L., Quadracci, L.J., Hatcher, B.L., Cerimele, B.J., DeSante, K.A. Clin. Pharmacol. Ther. (1993) [Pubmed]
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