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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The effects of histamine on skeletal muscle vasculature in cats.

1. Experiments have been made to determine the vascular effects of histamine and the mechanism of histamine-induced oedema formation in cat skeletal muscle. 2. Histamine caused dose-dependent dilatation of resistance vessels and increased intravascular volume over the dose range 1 X 10(-10)-1 X 10(-8) mol/kg min. The dilatation of resistance vessels resulted in dose-dependent increases in capillary hydrostatic pressure. 3. Histamine increased vascular permeability, as measured by accumulation of [131I]human serum albumin in the tissue, during infusions at 1 X 10(-8) mol/kg min but no albumin accumulation could be detected at lower infusion rates. 4. Oedema formation during histamine infusion of 1 X 10(-10) and 1 X 10(-9) mol/kg min seemed to be due to increases in capillary hydrostatic pressure and independent of increased vascular permeability. During infusions of histamine 1 X 10(-8) mol/kg min oedema was due predominantly to increased vascular permeability and to a lesser extent, the increase in capillary hydrostatic pressure.[1]


  1. The effects of histamine on skeletal muscle vasculature in cats. Flynn, S.B., Owen, D.A. J. Physiol. (Lond.) (1977) [Pubmed]
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