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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Progressive obstructive lung disease associated with microscopic polyangiitis.

Small airway involvement and progressive severe airflow obstruction are unexpected features in patients with microscopic polyangiitis. We report the case of a patient with microscopic polyangiitis and circulating anti-neutrophil cytoplasmic antibodies (ANCA), who developed pulmonary hyperinflation and airflow obstruction over a 7-yr period. Systemic manifestations of this vasculitis improved under corticosteriods and cyclophosphamid therapy, a treatment that did not influence either the very high level of anti-myeloperoxidase antibodies or the ventilatory impairment. Small airway involvement was suspected on the basis of pathologic small airway lesions and a mild emphysematous pattern on computed tomography (CT) scan, which was out of proportion with the severity of the obstructive lung disease.[1]

References

  1. Progressive obstructive lung disease associated with microscopic polyangiitis. Brugiere, O., Raffy, O., Sleiman, C., Groussard, O., Rothchild, E., Mellot, F., Jebrak, G., Mal, H., Roue, C., Pariente, R., Fournier, M. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
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