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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.

The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle progression in higher eukaryotes. This report describes the isolation of a novel, highly conserved 434 kDa protein, designated TRRAP, which interacts specifically with the c-Myc N terminus and has homology to the ATM/ PI3-kinase family. TRRAP also interacts specifically with the E2F-1 transactivation domain. Expression of transdominant mutants of the TRRAP protein or antisense RNA blocks c-Myc- and E1A-mediated oncogenic transformation. These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways.[1]

References

  1. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. McMahon, S.B., Van Buskirk, H.A., Dugan, K.A., Copeland, T.D., Cole, M.D. Cell (1998) [Pubmed]
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