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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Carbamazepine intoxication with negative myoclonus after the addition of clobazam.

We report a case a carbamazepine (CBZ) intoxication with negative myoclonus that occurred 4 weeks after clobazam (CLB) had been added to a stable regimen of CBZ and topiramate (TPM). Both CBZ and CBZ-epoxide (CBZ-E) blood levels were elevated, and the symptoms resolved quickly when CBZ dosage was reduced and CLB discontinued. CLB was reintroduced a year later with the patient's consent, and the time course of the interaction was studied: CBZ and CBZ-E levels increased slowly over 12 days. The interaction is thus probably related to the progressive increase in Nor-CLB.[1]


  1. Carbamazepine intoxication with negative myoclonus after the addition of clobazam. Genton, P., Nguyen, V.H., Mesdjian, E. Epilepsia (1998) [Pubmed]
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