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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Decreases in plasma A beta 1-40 levels with aging in non-demented elderly with ApoE-epsilon 4 allele.

This report examines plasma amyloid beta proteins A beta 40 and A beta 42 and apolipoprotein E (apoE) levels and their relationships with age in non-demented older adults with (N = 32) or without the apoE-epsilon 4 allele (N = 94). A beta levels did not differ between the groups whereas the epsilon 4 allele was associated with a significant reduction in plasma apoE. In subjects with the epsilon 4 allele, increasing age was associated with significant reduction in plasma A beta 40. Subjects without the epsilon 4 allele showed a significant positive correlation between A beta 40 and A beta 42 levels. There was also a significant correlation between plasma A beta 40 and apoE levels in all subjects.[1]

References

  1. Decreases in plasma A beta 1-40 levels with aging in non-demented elderly with ApoE-epsilon 4 allele. Pomara, N., Shao, B., Wisniewski, T., Mehta, P.D. Neurochem. Res. (1998) [Pubmed]
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