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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The relative expression amounts of apterous and its co-factor dLdb/ Chip are critical for dorso-ventral compartmentalization in the Drosophila wing.

Dorso-ventral axis formation in the Drosophila wing requires the localized accumulation of the Apterous LIM/homeodomain protein (Ap) in dorsal cells. Here we report that dLdb/ Chip encodes a LIM-binding cofactor that controls Ap activity. Both lack and excess of dLdb/ Chip function cause the same phenotype as apterous (ap) lack of function; i.e. dorsal to ventral transformations, generation of new wing margins, and wing outgrowths. These results indicate that the normal function of Ap in dorso-ventral compartmentalization requires the correct amount of the DLDB/CHIP co-factor, and suggest that the Ap and DLDB/CHIP proteins form a multimeric functional complex. In support of this model, we show that the dLdb/ Chip excess-of- function phenotypes can be rescued by ap overexpression.[1]

References

  1. The relative expression amounts of apterous and its co-factor dLdb/Chip are critical for dorso-ventral compartmentalization in the Drosophila wing. Fernández-Fúnez, P., Lu, C.H., Rincón-Limas, D.E., García-Bellido, A., Botas, J. EMBO J. (1998) [Pubmed]
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