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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Intravenous self-administration of gamma-hydroxybutyric acid in drug-naive mice.

The reinforcing effects of gamma-hydroxybutyric acid (GHB) were studied by means of intravenous self-administration in drug-naive mice. GHB self-administration was concentration-dependent (0.01-0.5 mg/kg/inj.) according to a bell-shaped curve. Pretreatment with the specific GHB receptor antagonist NCS-382 at a dose of 12.5 mg/kg i.p. completely antagonized the reinforcing effects of GHB. These data suggest that GHB is able to induce reinforcing effects in mice and support the hypothesis of an abuse liability of this drug.[1]


  1. Intravenous self-administration of gamma-hydroxybutyric acid in drug-naive mice. Martellotta, M.C., Cossu, G., Fattore, L., Gessa, G.L., Fratta, W. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1998) [Pubmed]
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