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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 

Your search matched a total of 24 documents. Results 1 - 10.

Homo sapiens
Gene: ... the radiosensitive phenotype of M059J cells appears to be due to a defect in PRKDC and a truncating ATM mutation...Disease relevance of PRKDC DNA- PK- deficient glioblastoma cells did not respond to insulin at the level of Ser- 473 phosphorylation; this effect was restored by complementation with the human PRKDC gene...
Mus musculus
Gene: ... - dependent protein kinase catalytic subunit) gene. Here, we show that ATM and Prkdc collaborate to maintain... between BALB/ c and STS for Prkdc. Because mice with combined disruptions of ATM and other NHEJ components... that is required to complete early embryogenesis in the absence of ATM. Anatomical context of Prkdc DNA- PKcs: a T...
Mus musculus
Gene: ... Disease relevance of Atm Patients with the human disorder ataxia- telangiectasia( A- T; refs 1, 2) and Atm- deficient mice have a pleiotropic phenotype that includes infertility. Critical role for Atm in suppressing V( D) J recombination- driven thymic lymphoma. By introducing a RAG- 1 deficiency into Atm... / Synonyms: Serine-protein kinase ATM
Mus musculus
Gene: ... was not different among the organ types, and immunohistochemistry revealed that all the organs expressed these two... their sensitivity to DNA damage. P53 was transiently phosphorylated at serine 23 during liver regeneration in an Atm... regulation of heterologous gene expression. BALB/ c alleles for Prkdc and Cdkn2a interact to modify tumor...
MeSH term: ... Disease relevance of Radiation Tolerance Whereas ataxia telangiectasia- mutated( ATM) kinase normally represses ceramide synthase, its derepression in Atm (-/-) mice increased crypt stem cell... sterility and enhanced radiation sensitivity in TLS (-/-) mice. ATM is the protein product of the gene...
Homo sapiens
Gene: ... , the other mutants defective in NER activities, the XRCC2 and XRCC3 mutants, and the XRCC5 mutant all showed... by down- regulation of XRCC5 and PRKDC genes. Linkage and association analysis of radiation damage repair... replication and repair, such as GADD45A, XRCC5 and PRKDC. Nuclear XRCC5 is normally extractable with non...
Mus musculus
Gene: ... aberrations. Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Inactivation..., similar to p53 deficiency, ataxia- telangiectasia- mutated( ATM) gene deficiency rescues the embryonic... proteins in the NHEJ pathway. Because mice with combined disruptions of ATM and other NHEJ components...
MeSH term: ... to bifunctional alkylating agents such as mitomycin C( MMC) and diepoxybutane( DEB). The ATM protein kinase...
Mus musculus
Gene: ... of these responses and is believed to function in an ataxia telangiectasia( Atm )- dependent manner. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated( ATM )- dependent and an ATM... in which the sites phosphorylated by ATM and ataxia telangiectasia and rad3 (+) related( ATR) were mutated...
Mus musculus
Gene: ... al ., 1995, Genomics 25: 604- 614). Variations in Prkdc encoding the catalytic subunit of DNA... to radiation- induced apoptosis. Atm and Bax cooperate in ionizing radiation- induced apoptosis in the central... evidence for Prkdc as a candidate for Rapop1 and a susceptibility gene for radiation lymphomagenesis...

 

 
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