Your search matched a total of 397 documents. Results 1 - 10.
Homo sapiens
Gene: ... role of PTEN in CNS pathophysiology. Overall, our data indicate that T- ALL cells inactivate PTEN... bile ducts of mutant mice at 2 months of age and continue to grow, leading to tumor formation in all...- resistant ALL line( EU- 1) resulted in decreased cell growth and enhanced sensitivity to doxorubicin... / Synonyms: PTEN1; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Mus musculus
Gene: ... Moreover, we observe a concordant loss of Pten and EGFR overexpression in nearly all high- grade gliomas... not exhibit this mutation, and in all cases have lost the wild- type Pten allele. Thus, mTor is required...Disease relevance of Pten RESULTS: Cdx- 2 expression correlates with PTEN along the length... / Synonyms: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Drosophila melanogaster
Gene: ... Disease relevance of Pten Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN. Hereditary mutation of PTEN causes tumor- susceptibility diseases such as Cowden..., as in mutants of the tumor suppressor PTEN. High impact information on Pten Pten is thus indispensable... / Synonyms: PTEN; PTEN3; dPTEN
Rattus norvegicus
Gene: ... Disease relevance of Pten These results suggest that alterations of the PTEN/ MMAC1 gene may not be involved in the development of adenocarcinomas induced by BHP in rats. High impact information on Pten Essential role of Pten in body size determination and pancreatic beta- cell homeostasis in vivo. Absence...
Canis lupus familiaris
Gene: ... Disease relevance of PTEN Our results document somatic point mutations or deletions encompassing the PTEN C- terminal domain in canine hemangiosarcoma that might provide cells a survival advantage within their microenvironment. High impact information on PTEN Expression of the PTEN tumor suppressor gene in malignant mammary...
Homo sapiens
Gene: ... , as an example. Chemical compound and disease context of PINK1 All sites of mutations were novel, suggesting... estimate will efficiently represent all of the common DNA variation in the entire gene. Genotyping... sequence analysis of all the coding and exon- intron junctions of the PINK1 using specific primer sets. We...
MeSH term: ... - induced skin tumors, but 70% of carcinomas from Pten +/- mice do not exhibit this mutation, and in all... of chemotherapeutic treatment for all tumors; for ovarian and small- cell lung carcinomas( SCLCs ), these levels were... in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Chemical compound and disease...
Homo sapiens
Gene: ... pseudogene. By sequence analysis of cDNA clones, we confirmed that all the mutations including these 4 rare...Disease relevance of PTENP1 Alterations of PTEN/ MMAC1, a candidate tumor suppressor gene, and its... status and protein expression include differences in the biological effect of specific PTEN mutations... / Synonyms: PTEN-rs; PTEN2; psiPTEN
MeSH term: ... in five of five glioblastomas, all of which also showed EGFr gene overexpression, but not in well... classification and regression- tree analysis of all 174 patients identified EGFR amplification as an independent... proliferation, supporting ASPM as a potential molecular target in glioblastoma. All responsive tumors were...
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Steven Johnsen and Donald R. Forsdyke and Kehinde Ross and Andrew Perry and Jonathan Eisen and A. Shimabukuro-Vornhagen and Giuseppe Rotondo and Gordon Laurie and Berkley Lynch and Kung-Hao Liang and Matthias Gstaiger and Thomas Pfeiffer and Marta Ramirez and Grant MacGregor and Jingyu Li and Fedik Rahimov and M El Gizouli and Marta Ramirez Gaite and Oswaldo Ribeiro-filho and Ralf Weigel and Bjoern Hamberger and Alexander Kanitz and Andreas Zankl and Chunming Ding and Maruf Yunus and Jonathan S. Berg and Michael Cariaso and Zakir Thomas and Monique Timberlake-Brady and LC Dore and Nan Shen and R. Eric Collins and Kuang-Mao Chiang and Brendan McMahon and John Chew and Wen-Ming Yang and Robert Hoffmann and J.B. Stewart and Manuela Cucerea and Ignacio García and William James and Thomas Kelder and Gregory Melahn and YINGDE ZHU and Andres Muro and Gabriel Santpere and Jeff Freilich and Junbin Qian and Steffen Poulsen and Eric Villard and Rafael Sidi and Grant Cramer and Chris Sander and Alexandre Chigaev and Florian Uhle and Carl Fulp and Andrew Brown and Xiaozhu Zhou and Corina Dutu and Hilary Spencer and david germano and Abbas Dehghan and Eung-ju PARK and Chris Sander and Albert Vilella and Miao Tian and Anjali Bheda and Michael Nevels and Jun Liu and D Delano and Chitose Taya and Soomi Cheong and David Kavanagh and Maha Karnoub and Hilmar Lapp and Christian Pallasch and Daniel Mietchen and Biju Balakrishnan and Keith Ashman and Juan Carlos Sobrino and Anshu Bhardwaj and Grzegorz Wickiel and Matthew Day and Anthony Sebastian and Vedran Katavic and Liang Long and Barry Wanner and Sarah Snelling and Fernando Montanes and Omobosede Fashedemi and Gustavo Cervantes and Manoj Kumar and Edward D Great and Paul Paukstelis and Roy Soetikno and Ana I Caño-Delgado and Minsoo Choi and Lei Wang and Brenda Riley and A Michelle Moon and Jon Moulton and Mahmoud Elshahawy and Meagan Gillespie and Banundari Rachmawati and Qian Han and Eric Danner and Xavier Fouillet and Madhusudhan Acharya and Brian Young and Chandra Sekhar Mukhopadhyay and shrawan bhattacharjee and Marieke van der Linden and cj hoban and Sandi Pniauskas and jackie gao and Metin Bilgin and Gillian L. Dalgliesh and Karl Wotton and Iveta Herichova and Yuji Morita and Marta Hernandez and Gregor Krings and Marco Briones and Tim D. Smith and Yiumo Michael Chan and Zhenyu Guo and Barry Barclay and Hong Wang and tarali chowdhury and Tilman Brummer and Nuno Faria and Tamir Ben David and Myles Axton and Yannick Fonseca and Francis Castets and Modesto Redrejo-Rodríguez and Bruce Herron and Toshio Fujita and Elena Puccetti and Zhang Zhang and John Osborne and Illes J Farkas and Fernando Andres and Phyllis Pugh and Jonathan Court and Tim Vickers and Nir Friedman and Holger Dick and Ya-Chen Liang and Jonathan Froehlich and Haitham Sobhy and David Abraham and Stephane Krief and Yaroslav Nikolaev and Qiping Feng and d gupta and R Thapar and Susan Wee and Michael Rehman and SOUMITRA GHOSH and Mohamed Eweida and Cedric Uytingco and Nie hongchuan and David Steenblock and Mark A. Kukucka and Zoli Fekete and Sergei Kozlov and Javier Jara and Osama Naguib and Felix Benninger and jean-marc lo-guidice and VASUDEVA BHAT and Anne O. Summers and Bjoern Titz and Anna Levine and Klas Udekwu and Robert Hoffmann
