Gene Review:
PINK1 - PTEN induced putative kinase 1
Homo sapiens
Synonyms:
BRPK, PARK6, Serine/threonine-protein kinase PINK1, mitochondrial
- Novel PINK1 mutations in early-onset parkinsonism. Hatano, Y., Li, Y., Sato, K., Asakawa, S., Yamamura, Y., Tomiyama, H., Yoshino, H., Asahina, M., Kobayashi, S., Hassin-Baer, S., Lu, C.S., Ng, A.R., Rosales, R.L., Shimizu, N., Toda, T., Mizuno, Y., Hattori, N. Ann. Neurol. (2004)
- Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Valente, E.M., Abou-Sleiman, P.M., Caputo, V., Muqit, M.M., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A.R., Healy, D.G., Albanese, A., Nussbaum, R., González-Maldonado, R., Deller, T., Salvi, S., Cortelli, P., Gilks, W.P., Latchman, D.S., Harvey, R.J., Dallapiccola, B., Auburger, G., Wood, N.W. Science (2004)
- Tickled PINK1: Mitochondrial homeostasis and autophagy in recessive Parkinsonism. Chu, C.T. Biochim. Biophys. Acta. (2009)
- Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. Marongiu, R., Spencer, B., Crews, L., Adame, A., Patrick, C., Trejo, M., Dallapiccola, B., Valente, E.M., Masliah, E. J. Neurochem. (2009)
- PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Gandhi, S., Wood-Kaczmar, A., Yao, Z., Plun-Favreau, H., Deas, E., Klupsch, K., Downward, J., Latchman, D.S., Tabrizi, S.J., Wood, N.W., Duchen, M.R., Abramov, A.Y. Mol. Cell. (2009)
- Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. Dagda, R.K., Cherra SJ, 3.r.d., Kulich, S.M., Tandon, A., Park, D., Chu, C.T. J. Biol. Chem. (2009)
- Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. Sandebring, A., Thomas, K.J., Beilina, A., van der Brug, M., Cleland, M.M., Ahmad, R., Miller, D.W., Zambrano, I., Cowburn, R.F., Behbahani, H., Cedazo-Mínguez, A., Cookson, M.R. PLoS. One. (2009)
- The biochemistry of Parkinson's disease. Cookson, M.R. Annu. Rev. Biochem. (2005)
- Parkin blushed by PINK1. Tan, J.M., Dawson, T.M. Neuron (2006)
- C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1. Sim, C.H., Lio, D.S., Mok, S.S., Masters, C.L., Hill, A.F., Culvenor, J.G., Cheng, H.C. Hum. Mol. Genet. (2006)
- The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. Meissner, C., Lorenz, H., Weihofen, A., Selkoe, D.J., Lemberg, M.K. J. Neurochem. (2011)
- PINK1- and Parkin-mediated mitophagy at a glance. Jin, S.M., Youle, R.J. J. Cell. Sci. (2012)
- Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through Protein Kinase A. Dagda, R.K., Pien, I., Wang, R., Zhu, J., Wang, K.Z., Callio, J., Banerjee, T.D., Dagda, R.Y., Chu, C.T. J. Neurochem. (2013)
- Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism. Li, Y., Tomiyama, H., Sato, K., Hatano, Y., Yoshino, H., Atsumi, M., Kitaguchi, M., Sasaki, S., Kawaguchi, S., Miyajima, H., Toda, T., Mizuno, Y., Hattori, N. Neurology (2005)
- PINK1 mutations in sporadic early-onset Parkinson's disease. Tan, E.K., Yew, K., Chua, E., Puvan, K., Shen, H., Lee, E., Puong, K.Y., Zhao, Y., Pavanni, R., Wong, M.C., Jamora, D., de Silva, D., Moe, K.T., Woon, F.P., Yuen, Y., Tan, L. Mov. Disord. (2006)
- PINK1 protein in normal human brain and Parkinson's disease. Gandhi, S., Muqit, M.M., Stanyer, L., Healy, D.G., Abou-Sleiman, P.M., Hargreaves, I., Heales, S., Ganguly, M., Parsons, L., Lees, A.J., Latchman, D.S., Holton, J.L., Wood, N.W., Revesz, T. Brain (2006)
- Management: the indomitable Mr. Pink. Whistle-blowers. Interview by Toni Turner. Pink, G. Nursing times. (1992)
- Mitochondria and dopamine: new insights into recessive parkinsonism. Shen, J., Cookson, M.R. Neuron (2004)
- Characterizing T-cell epitopes in vaccine candidates. Pink, J.R., Sinigaglia, F. Immunol. Today (1989)
- Regulation of methylbenzoate emission after pollination in snapdragon and petunia flowers. Negre, F., Kish, C.M., Boatright, J., Underwood, B., Shibuya, K., Wagner, C., Clark, D.G., Dudareva, N. Plant Cell (2003)
- Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y. Deng, H., Jankovic, J., Guo, Y., Xie, W., Le, W. Biochem. Biophys. Res. Commun. (2005)
- Juvenile-onset Parkinsonism as a result of the first mutation in the adenosine triphosphate orientation domain of PINK1. Leutenegger, A.L., Salih, M.A., Ibáñez, P., Mukhtar, M.M., Lesage, S., Arabi, A., Lohmann, E., Dürr, A., Ahmed, A.E., Brice, A. Arch. Neurol. (2006)
- Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: an 18F-dopa PET study. Khan, N.L., Valente, E.M., Bentivoglio, A.R., Wood, N.W., Albanese, A., Brooks, D.J., Piccini, P. Ann. Neurol. (2002)
- The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. Scheele, C., Petrovic, N., Faghihi, M.A., Lassmann, T., Fredriksson, K., Rooyackers, O., Wahlestedt, C., Good, L., Timmons, J.A. BMC Genomics (2007)
- The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism. Healy, D.G., Abou-Sleiman, P.M., Ahmadi, K.R., Muqit, M.M., Bhatia, K.P., Quinn, N.P., Lees, A.J., Latchmann, D.S., Goldstein, D.B., Wood, N.W. Ann. Neurol. (2004)
- PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1. Pridgeon, J.W., Olzmann, J.A., Chin, L.S., Li, L. PLoS. Biol. (2007)
- The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Plun-Favreau, H., Klupsch, K., Moisoi, N., Gandhi, S., Kjaer, S., Frith, D., Harvey, K., Deas, E., Harvey, R.J., McDonald, N., Wood, N.W., Martins, L.M., Downward, J. Nat. Cell. Biol. (2007)
- PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. Wood-Kaczmar, A., Gandhi, S., Yao, Z., Abramov, A.Y., Miljan, E.A., Keen, G., Stanyer, L., Hargreaves, I., Klupsch, K., Deas, E., Downward, J., Mansfield, L., Jat, P., Taylor, J., Heales, S., Duchen, M.R., Latchman, D., Tabrizi, S.J., Wood, N.W. PLoS. ONE. (2008)
- Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells. Gegg, M.E., Cooper, J.M., Schapira, A.H., Taanman, J.W. PLoS. ONE. (2009)
- Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Wang, D., Qian, L., Xiong, H., Liu, J., Neckameyer, W.S., Oldham, S., Xia, K., Wang, J., Bodmer, R., Zhang, Z. Proc. Natl. Acad. Sci. U. S. A. (2006)
- FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation. Mei, Y., Zhang, Y., Yamamoto, K., Xie, W., Mak, T.W., You, H. Proc. Natl. Acad. Sci. U. S. A. (2009)
- Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. Exner, N., Treske, B., Paquet, D., Holmström, K., Schiesling, C., Gispert, S., Carballo-Carbajal, I., Berg, D., Hoepken, H.H., Gasser, T., Krüger, R., Winklhofer, K.F., Vogel, F., Reichert, A.S., Auburger, G., Kahle, P.J., Schmid, B., Haass, C. J. Neurosci. (2007)
- A pivotal role for PINK1 and autophagy in mitochondrial quality control: implications for Parkinson disease. Chu, C.T. Hum. Mol. Genet. (2010)
- The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Deng, H., Dodson, M.W., Huang, H., Guo, M. Proc. Natl. Acad. Sci. U. S. A. (2008)
- Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Yang, Y., Ouyang, Y., Yang, L., Beal, M.F., McQuibban, A., Vogel, H., Lu, B. Proc. Natl. Acad. Sci. U. S. A. (2008)
- The PINK1/Parkin pathway regulates mitochondrial morphology. Poole, A.C., Thomas, R.E., Andrews, L.A., McBride, H.M., Whitworth, A.J., Pallanck, L.J. Proc. Natl. Acad. Sci. U. S. A. (2008)
- Mitochondrial aberrations in mucolipidosis Type IV. Jennings JJ, J.r., Zhu, J.H., Rbaibi, Y., Luo, X., Chu, C.T., Kiselyov, K. J. Biol. Chem. (2006)
- Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Park, J., Lee, S.B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.M., Chung, J. Nature. (2006)
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. Narendra, D., Tanaka, A., Suen, D.F., Youle, R.J. J. Cell. Biol. (2008)
- Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Beilina, A., Van Der Brug, M., Ahmad, R., Kesavapany, S., Miller, D.W., Petsko, G.A., Cookson, M.R. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Hoepken, H.H., Gispert, S., Morales, B., Wingerter, O., Del Turco, D., Mülsch, A., Nussbaum, R.L., Müller, K., Dröse, S., Brandt, U., Deller, T., Wirth, B., Kudin, A.P., Kunz, W.S., Auburger, G. Neurobiol. Dis. (2007)
- Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Clark, I.E., Dodson, M.W., Jiang, C., Cao, J.H., Huh, J.R., Seol, J.H., Yoo, S.J., Hay, B.A., Guo, M. Nature (2006)
- Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. Muqit, M.M., Abou-Sleiman, P.M., Saurin, A.T., Harvey, K., Gandhi, S., Deas, E., Eaton, S., Payne Smith, M.D., Venner, K., Matilla, A., Healy, D.G., Gilks, W.P., Lees, A.J., Holton, J., Revesz, T., Parker, P.J., Harvey, R.J., Wood, N.W., Latchman, D.S. J. Neurochem. (2006)
- Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease. Tang, B., Xiong, H., Sun, P., Zhang, Y., Wang, D., Hu, Z., Zhu, Z., Ma, H., Pan, Q., Xia, J.H., Xia, K., Zhang, Z. Hum. Mol. Genet. (2006)
- Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit? Hedrich, K., Hagenah, J., Djarmati, A., Hiller, A., Lohnau, T., Lasek, K., Grünewald, A., Hilker, R., Steinlechner, S., Boston, H., Kock, N., Schneider-Gold, C., Kress, W., Siebner, H., Binkofski, F., Lencer, R., Münchau, A., Klein, C. Arch. Neurol. (2006)
- T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease. Chishti, M.A., Bohlega, S., Ahmed, M., Loualich, A., Carroll, P., Sato, C., St George-Hyslop, P., Westaway, D., Rogaeva, E. Arch. Neurol. (2006)
- Clinical features and gene analysis in Korean patients with early-onset Parkinson disease. Chung, E.J., Ki, C.S., Lee, W.Y., Kim, I.S., Kim, J.Y. Arch. Neurol. (2006)
- Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. Petit, A., Kawarai, T., Paitel, E., Sanjo, N., Maj, M., Scheid, M., Chen, F., Gu, Y., Hasegawa, H., Salehi-Rad, S., Wang, L., Rogaeva, E., Fraser, P., Robinson, B., St George-Hyslop, P., Tandon, A. J. Biol. Chem. (2005)
- Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7. Bonifati, V., Dekker, M.C., Vanacore, N., Fabbrini, G., Squitieri, F., Marconi, R., Antonini, A., Brustenghi, P., Dalla Libera, A., De Mari, M., Stocchi, F., Montagna, P., Gallai, V., Rizzu, P., van Swieten, J.C., Oostra, B., van Duijn, C.M., Meco, G., Heutink, P. Neurol. Sci. (2002)
- Genetic and DAT imaging studies of familial parkinsonism in a Taiwanese cohort. Lu, C.S., Chou, Y.H., Weng, Y.H., Chen, R.S. J. Neural Transm. Suppl. (2006)
- PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism. Klein, C., Djarmati, A., Hedrich, K., Schäfer, N., Scaglione, C., Marchese, R., Kock, N., Schüle, B., Hiller, A., Lohnau, T., Winkler, S., Wiegers, K., Hering, R., Bauer, P., Riess, O., Abbruzzese, G., Martinelli, P., Pramstaller, P.P. Eur. J. Hum. Genet. (2005)
- Homozygous and heterozygous PINK1 mutations: considerations for diagnosis and care of Parkinson's disease patients. Zadikoff, C., Rogaeva, E., Djarmati, A., Sato, C., Salehi-Rad, S., St George-Hyslop, P., Klein, C., Lang, A.E. Mov. Disord. (2006)