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Chemical Compound Review

AC1MI0A2     [(2R,5R)-5-(2-amino-7-methyl- 6-oxo-3,8...

Synonyms: 7-Methyl-dgmp, 7-Methyl-2'-deoxyguanosine 3'-monophosphate
 
 
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Disease relevance of 7-Methyl-dgmp

 

High impact information on 7-Methyl-dgmp

  • CYP2D6 and CYP2E1 genotypes are associated with higher 7-methyl-dGMP levels, while the GSTM1 null genotype is associated with higher numbers of PAH-dGMP adducts [1].
  • PURPOSE: Using DNA-adduct detection methods specific for 7-methyl-dGMP and PAH-dGMP, we sought to determine whether an inherited genetic susceptibility to cancer associated with certain carcinogen-metabolizing and detoxifying genes (e.g., cytochrome P450 and glutathione S-transferase) is related to DNA adduct formation in lung tissue [1].
  • When different concentrations of the adducts were tested, a complete phosphorylation was noted for 7-methyl-dGMP to the lowest tested amount of 1 fmol [2].
 

Analytical, diagnostic and therapeutic context of 7-Methyl-dgmp

  • A sensitive and highly specific assay for the detection of 7-methyl-2'-deoxyguanosine-3'-monophosphate (7-methyldGp) and 7-ethyl-2'-deoxyguanosine-3'-monophosphate (7-ethyldGp) has been developed by combining two different HPLC purification steps with the 32P-postlabeling assay [3].

References

  1. Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo. Kato, S., Bowman, E.D., Harrington, A.M., Blomeke, B., Shields, P.G. J. Natl. Cancer Inst. (1995) [Pubmed]
  2. 32P-postlabelling of 2-hydroxyethylated, ethylated and methylated adducts of 2'-deoxyguanosine 3'-monophosphate. Koivisto, P., Hemminki, K. Carcinogenesis (1990) [Pubmed]
  3. 7-Alkyldeoxyguanosine adduct detection by two-step HPLC and the 32P-postlabeling assay. Kato, S., Petruzzelli, S., Bowman, E.D., Turteltaub, K.W., Blomeke, B., Weston, A., Shields, P.G. Carcinogenesis (1993) [Pubmed]
 
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