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Chemical Compound Review

Ara-AMP     [(2R,3S,4S,5R)-5-(6- aminopurin-9-yl)-3,4...

Synonyms: araAMP, Arabino-AMP, SureCN144996, CI-808, VIDARABINE PHOSPHATE, ...
 
 
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Disease relevance of VIDARABINE PHOSPHATE

 

High impact information on VIDARABINE PHOSPHATE

 

Chemical compound and disease context of VIDARABINE PHOSPHATE

 

Biological context of VIDARABINE PHOSPHATE

  • The efficiency of phosphorylation of araAMP to araATP is about 5% of that of AMP, as estimated from their Vmax/Km ratios for PRPP synthetase [9].

References

  1. Two approaches that increase the activity of analogs of adenine nucleosides in animal cells. Plunkett, W., Cohen, S.S. Cancer Res. (1975) [Pubmed]
  2. Antiproliferative effects of 9-beta-D-arabinofuranosyladenine 5'-monophosphate and related compounds in combination with adenosine deaminase inhibitors against mouse leukemia L1210/C2 cells in culture. Cass, C.E., Tan, T.H., Selner, M. Cancer Res. (1979) [Pubmed]
  3. Herpes simplex virus type I DNA polymerase. Kinetic properties of the associated 3'-5' exonuclease activity and its role in araAMP incorporation. Derse, D., Cheng, Y.C. J. Biol. Chem. (1981) [Pubmed]
  4. Effect of 9-beta-D-arabinofuranosyladenine 5'-monophosphate and 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate on experimental herpes simplex keratitis. Kaufman, H.E., Varnell, E.D. Antimicrob. Agents Chemother. (1976) [Pubmed]
  5. Antiviral activity of a conjugate of adenine-9-beta-D-arabinofuranoside 5'-monophosphate and a 9 kDa fragment of arabinogalactan. Josephson, L., Rutkowski, J.V., Paul, K., Frigo, T., Korba, B.E., Tennant, B., Groman, E.V. Antivir. Ther. (Lond.) (1996) [Pubmed]
  6. Enhancement of 9-beta-d-arabinofuranosyladenine cytotoxicity to mouse leukemia L1210 in vitro by 2'-deoxycoformycin. Cass, C.E., Au-Yeung, T.H. Cancer Res. (1976) [Pubmed]
  7. Inhibition of fructose 1,6-bisphosphatase by 9-beta-D-arabinofuranosyladenine 5'-monophosphate. Marcus, F. Cancer Res. (1976) [Pubmed]
  8. Chemotherapy of herpes simplex virus encephalitis in mice by direct intracerebral injection. Cameron, K.R., Adams, D.H. J. Infect. Dis. (1979) [Pubmed]
  9. 9-Beta-D-arabinofuranosyladenine 5'-monophosphate (araAMP) is converted directly to its antivirally active 5'-triphosphate form by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase. Balzarini, J., De Clercq, E. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  10. Inhibition of the herpes simplex virus-coded thymidine kinase-complex by 9-beta-D-arabinofuranosyladenine 5'-monophosphate (ara-AMP) and 9-(2-hydroxyethoxymethyl)guanine-monophosphate (acyclo-GMP). Labenz, J., Müller, W.E., Falke, D. Arch. Virol. (1984) [Pubmed]
 
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