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Chemical Compound Review

Trimebutine maleate     dimethyl-[2-phenyl-1-(3,4,5...

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Disease relevance of Trimebutine maleate


High impact information on Trimebutine maleate


Biological context of Trimebutine maleate


Anatomical context of Trimebutine maleate


Associations of Trimebutine maleate with other chemical compounds


Gene context of Trimebutine maleate


Analytical, diagnostic and therapeutic context of Trimebutine maleate


  1. Effects of trimebutine maleate on gastric motility in patients with gastric ulcer. Kamiya, T., Nagao, T., Andou, T., Misu, N., Kobayashi, Y., Hirako, M., Hara, M., Fujinami, T. J. Gastroenterol. (1998) [Pubmed]
  2. The effect of trimebutine maleate on gastric emptying in patients with non-ulcer dyspepsia. Aktas, A., Caner, B., Ozturk, F., Bayhan, H., Narin, Y., Mentes, T. Annals of nuclear medicine. (1999) [Pubmed]
  3. Effects of trimebutine on intestinal motility after massive small bowel resection. Uchiyama, M., Iwafuchi, M., Yagi, M., Iinuma, Y., Kanada, S., Ohtaki, M., Homma, S. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. (2000) [Pubmed]
  4. Local actions of trimebutine maleate in canine small intestine. Daniel, E.E., Kostolanska, F., Allescher, H.D., Ahmad, S., Fox, J.E. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  5. Effects of trimebutine on cytosolic Ca2+ and force transitions in intestinal smooth muscle. Nagasaki, M., Kobayashi, T., Tamaki, H. Eur. J. Pharmacol. (1991) [Pubmed]
  6. Allosteric interaction of trimebutine maleate with dihydropyridine binding sites. Nagasaki, M., Kurosawa, H., Naito, K., Tamaki, H. Eur. J. Pharmacol. (1990) [Pubmed]
  7. Effect of trimebutine maleate on sinus node pacemaker activity of the rabbit. Kotake, H., Kinugawa, T., Hirai, S., Fukugi, M., Hasegawa, J., Mashiba, H. Eur. J. Pharmacol. (1987) [Pubmed]
  8. Pharmacokinetic and bioequivalence evaluation of two formulations of 100 mg trimebutine maleate (Recutin and Polybutin) in healthy male volunteers using the LC-MS/MS method. Jhee, O.H., Lee, Y.S., Shaw, L.M., Jeon, Y.C., Lee, M.H., Lee, S.H., Kang, J.S. Clin. Chim. Acta (2007) [Pubmed]
  9. The action of trimebutine maleate on gastrointestinal motility is mediated by opiate receptors in human subjects. Valori, R., Shannon, S., Reddy, N., Daniel, E.E., Collins, S.M. Gastroenterol. Clin. Biol. (1987) [Pubmed]
  10. Effect of trimebutine maleate on emptying of stomach and gallbladder and release of gut peptide following a solid meal in man. Okano, H., Saeki, S., Inui, A., Kawai, Y., Ohno, S., Morimoto, S., Ohmoto, A., Nakashima, T., Miyamoto, M., Okita, M. Dig. Dis. Sci. (1993) [Pubmed]
  11. Determination of trimebutine maleate in rat plasma and tissues by using capillary zone electrophoresis. Li, F., Yu, L. Biomed. Chromatogr. (2001) [Pubmed]
  12. Effects of trimebutine maleate on delayed rectifier K+ currents in guinea-pig ventricular myocytes. Morisawa, T., Hasegawa, J., Tanabe, K., Watanabe, A., Kitano, M., Kishimoto, Y. J. Pharm. Pharmacol. (2000) [Pubmed]
  13. Effects of trimebutine maleate on electrical activities of isolated mammalian cardiac preparations. Igawa, O., Kotake, H., Hirai, S., Hisatome, I., Hasegawa, J., Mashiba, H. J. Pharm. Pharmacol. (1989) [Pubmed]
  14. Effect of trimebutine maleate on the contractile response of the isolated ileum from diabetic rats. Uchida, M., Iwata, T., Takagi, S., Sugiyama, Y., Ishitani, K., Honda, H., Sakai, Y. Gen. Pharmacol. (1994) [Pubmed]
  15. Effects of orally vs. parenterally administrated trimebutine on gastrointestinal and colonic motility in dogs. Buéno, L., Hondé, C., Pascaud, X., Junien, J.L. Gastroenterol. Clin. Biol. (1987) [Pubmed]
  16. Effects of erythromycin in chronic idiopathic intestinal pseudo-obstruction. Minami, T., Nishibayashi, H., Shinomura, Y., Matsuzawa, Y. J. Gastroenterol. (1996) [Pubmed]
  17. Effects of trimebutine maleate (TM-906) on electrical and mechanical activities of smooth muscles of the guinea-pig stomach. Furukawa, K., Kimoto, Y. Jpn. J. Pharmacol. (1984) [Pubmed]
  18. Effect of antispasmodic drugs on the colonic motility. Part II: Clinical study in man. Sasaki, D., Kido, A., Yoshida, Y. International journal of clinical pharmacology, therapy, and toxicology. (1984) [Pubmed]
  19. Pharmacokinetics and bioequivalence of two trimebutine formulations in healthy volunteers using desmethyl-trimebutine levels. Saivin, S., Lavit, M., Michel, F., Labaune, J.P., Martin, A., Cahiez, G., Donazzolo, C., Chomard, J.M., Houin, G. Arzneimittel-Forschung. (2000) [Pubmed]
  20. Quantitative determination of trimebutine maleate and its three metabolites in human plasma by liquid chromatography-tandem mass spectrometry. Wang, H., Zhou, H., Horimoto, S., Jiang, J., Mayumi, T., Hu, P. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2002) [Pubmed]
  21. Determination of trimebutine and desmethyl-trimebutine in human plasma by HPLC. Lavit, M., Saivin, S., Boudra, H., Michel, F., Martin, A., Cahiez, G., Labaune, J.P., Chomard, J.M., Houin, G. Arzneimittel-Forschung. (2000) [Pubmed]
  22. Pharmacokinetic study of trimebutine maleate in rabbit blood using in vivo microdialysis coupled to capillary electrophoresis. Wang, L., Zhang, Z., Yang, W. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
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