Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Dracorhodin 5-methoxy-6-methyl-2-phenyl- chromen-7-one

Synonyms: CHEMBL486600, NSC-234485, AC1Q6ABQ, NSC234485, AR-1G8711, ...

Xia, M.Y. et al., Xia, M. et al.

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High impact information on Dracorhodin

Taken together, dracorhodin perchlorate-induced apoptosis in HL-60 cells via up-regulation of Bax, activation of caspases and ERK/p38/JNK MAPKs [1].
Dracorhodin perchlorate induces apoptosis in HL-60 cells [1].
Caspase -1, -3, -8, -9, and -10 inhibitors partially reversed the cell death induced by dracorhodin perchlorate [1].
Taken together, our results indicate that dracorhodin perchlorate alters the intracellular redox status, changed the balance of Bcl-X(L) and Bax protein expression, and induces apoptosis through caspase pathways in HeLa cells [2].

Anatomical context of Dracorhodin

Dracorhodin perchlorate, an anthocyanin red pigment, induces human premyelocytic leukemia HL-60 cell death through apoptotic pathway [1].

References

Dracorhodin perchlorate induces apoptosis in HL-60 cells. Xia, M.Y., Wang, M.W., Cui, Z., Tashiro, S.I., Onodera, S., Minami, M., Ikejima, T. Journal of Asian natural products research. (2006) [Pubmed]
Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species. Xia, M., Wang, D., Wang, M., Tashiro, S., Onodera, S., Minami, M., Ikejima, T. J. Pharmacol. Sci. (2004) [Pubmed]

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