Disease relevance of N-cyclohexylcyclohexanamine

• Growth characteristics, polyamine levels, and distribution of cells in the cell cycle were determined for 9L rat brain tumor cells treated for various periods with 1 mM dicyclohexylamine sulfate (DCHA) [1].
• The effect of dicyclohexylamine on seven freshly isolated bacterial strains of mastitis pathogens was studied [2].
• Micrococcus sp. and Klebsiella sp. grew in the presence of 10.0 mM-dicyclohexylamine, and, finally the growth of Streptococcus agalactiae was not at all affected by dicyclohexylamine [2].
• The effects of dicyclohexylamine on polyamine biosynthesis and incorporation into turnip yellow mosaic virus in Chinese cabbage protoplasts infected in vitro [3].
• Dicyclohexylamine, a spermidine synthase inhibitor, was evaluated for its ability to alter specific polyamine levels in rat hepatoma HTC cells in culture [4].

High impact information on N-cyclohexylcyclohexanamine

• Effects of dicyclohexylamine sulfate, a spermidine synthase inhibitor, in 9L rat brain tumor cells [1].
• Dicyclohexylamine is not an inhibitor of spermidine synthase [5].
• Reversible inhibition of bacterial growth after specific inhibition of spermidine synthase by dicyclohexylamine [2].
• Our earlier proposed activation of POCl(3) is confirmed here by preparing pure Cl(2)P(O)OH and its potassium and dicyclohexylamine salts that reproduce the action of POCl(3) as in vitro AChE inhibitors and toxicants in mice [6].
• This is accomplished using a covalent amide coupling reaction that incorporates dicyclohexylamine (DCHA) headgroups on the surface of mercaptoacetic acid (MAA) functionalized gold nanoparticles [7].

Biological context of N-cyclohexylcyclohexanamine

• N-Nitrosodicyclohexylamine (N-NO-DCHA) can be formed by nitrosation from dicyclohexylamine during the application of these formulations [8].

Anatomical context of N-cyclohexylcyclohexanamine

• Electron microscopy showed a loss of flagella in spermidine-deficient bacteria: after 24 h 70% 85% of bacteria grown in the presence of dicyclohexylamine did not have flagella, whereas bacteria grown in the presence of dicyclohexylamine and spermidine had flagella [9].
• Studies on the modes of action of dicyclohexylamine and related amines with a potentiating effect on noradrenaline responses in the rat vas deferens [10].

Associations of N-cyclohexylcyclohexanamine with other chemical compounds

• Putrescine reversed the inhibition only when bacteria had a spermidine synthase activity insensitive to dicyclohexylamine [2].
• Spermidine synthase activity was markedly inhibited in vitro by dicyclohexylamine (50% inhibition at 3 microM) and cyclohexylamine (50% inhibition at 15 microM); both being competitive inhibitors with respect to putrescine [11].
• When cells were stimulated by serum addition, the presence of dicyclohexylamine caused an extraordinarily large induction in ornithine decarboxylase in spite of the abnormally high levels of both putrescine and spermine [4].

Gene context of N-cyclohexylcyclohexanamine

• Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity [4].

Analytical, diagnostic and therapeutic context of N-cyclohexylcyclohexanamine

• Crystallization of 7 and acid 8 as its dicyclohexylamine salt gave excellent impurity rejection [12].
• Oral administration of the substances to the rat was followed by their renal excretion as mercapturic acids, which were isolated as dicyclohexylamine salts [13].

References