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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

AP4S1  -  adaptor-related protein complex 4, sigma 1...

Homo sapiens

Synonyms: AP-4 adaptor complex subunit sigma-1, AP-4 complex subunit sigma-1, AP47B, Adaptor-related protein complex 4 subunit sigma-1, CLA20, ...
 
 
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Disease relevance of AP4S1

  • No adverse effects were seen in the CLA20 group, whereas indications of increased bone resorption rate were observed in the CLA40 group [1].
 

High impact information on AP4S1

  • The results indicate anti-inflammatory effects and enhanced T-cell function for the CLA20 group [1].
  • In vitro interleukin 2 (IL-2) production increased, and tumor necrosis factor alpha, IL-1beta, prostaglandin E2, and leukotriene B4 production decreased in the CLA20 group [1].

References

  1. Effects of cis-9,trans-11 CLA in rats at intake levels reported for breast-fed infants. Turpeinen, A.M., von Willebrand, E., Salminen, I., Linden, J., Basu, S., Rai, D. Lipids (2006) [Pubmed]
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