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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NXPH4  -  neurexophilin 4

Homo sapiens

Synonyms: NPH4, Neurexophilin-4, UNQ1928/PRO4403
 
 
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High impact information on NXPH4

  • In addition, NPH-4 is required for the localization of NPH-1 to this domain [1].
  • NPH4 significantly inhibited both lipid peroxidation and the associated increase of electrophoretic mobility of ApoB protein [2].
  • Furthermore, NPH4 suppressed the uptake of oxidized [14C]oleyl-esterified LDL by the macrophage-like cell line J774 [2].
  • Since oxidative modification of low-density lipoprotein (LDL) and uptake of the oxidized LDL by macrophages are closely related to the pathogenesis of atherosclerosis, we examined the inhibitory effect of 5,6,7,8-tetrahydroneopterin (NPH4) on Cu(II)-induced lipid peroxidation of LDL [2].
  • The hydroxyl radical spin adduct was also observed in the solution containing NPH-4 and XOD but excluding HPX [3].
 

Associations of NXPH4 with chemical compounds

 

Enzymatic interactions of NXPH4

  • These results indicate that NPH-4 is readily oxidized to some intermediates before the reaction with oxygen free radicals and that the substance which actually serves as an antioxidant in vivo is not NPH-4 but its metabolites [3].

References

  1. The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception. Winkelbauer, M.E., Schafer, J.C., Haycraft, C.J., Swoboda, P., Yoder, B.K. J. Cell. Sci. (2005) [Pubmed]
  2. Effect of 5,6,7,8-tetrahydroneopterin on oxidative modification of low-density lipoprotein, and its uptake in the macrophage-like cell line J774. Iizuka, H., Watanabe, Y., Kojima, S. Jpn. J. Pharmacol. (1996) [Pubmed]
  3. Does the reduced form of neopterin serve as an antioxidant? Mori, H., Arai, T., Mori, K., Suzuki, T., Makino, K. Biochem. Mol. Biol. Int. (1996) [Pubmed]
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