High impact information on CDCA5

• We speculate that the protein, which we have named sororin, regulates the ability of the cohesin complex to mediate sister chromatid cohesion, perhaps by altering the nature of the interaction of cohesin with the chromosomes [1].
• Regulation of centromeric cohesion by sororin independently of the APC/C [2].
• These phenotypes are similar to those seen after Shugoshin depletion, suggesting that sororin and Shugoshin might act in concert [2].
• Sororin-depleted cells reach prometaphase with cohered sister chromatids and are able to form metaphase plates [2].
• Sororin, the cell cycle and sister chromatid cohesion [3].

Biological context of CDCA5

• Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates [1].
• Ubiquitination by the APC and the resulting degradation ensure that sororin levels are low throughout G1 and only rise during S phase [3].
• Interestingly, we identified sororin in a screen for proteins whose levels are controlled by the Anaphase Promoting Complex (APC), a cell cycle-regulated ubiquitin ligase [3].

References