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SLC2A13  -  solute carrier family 2 (facilitated...

Homo sapiens

Synonyms: Hmit, HMIT, H(+)-myo-inositol cotransporter, H(+)-myo-inositol symporter, MGC48624, ...
 
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High impact information on SLC2A13

  • Here we describe the identification and functional characterization of a novel H(+)-myo- inositol co-transporter, HMIT, expressed predominantly in the brain [1].
  • Immunofluorescence microscopy analysis showed HMIT expression in glial cells and some neurons [1].
  • Functional expression of HMIT in Xenopus oocytes showed that transport activity was specific for myo-inositol and related stereoisomers with a Michaelis-Menten constant of approximately 100 microM, and that transport activity was strongly stimulated by decreasing pH [1].
  • Much remains to be learned about the transport functions of the recently discovered isoforms (GLUT6-13 and HMIT) and their physiological role in the metabolism of glucose, myo-inositol and perhaps other substrates [2].

References

  1. Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. Uldry, M., Ibberson, M., Horisberger, J.D., Chatton, J.Y., Riederer, B.M., Thorens, B. EMBO J. (2001)
  2. The SLC2 family of facilitated hexose and polyol transporters. Uldry, M., Thorens, B. Pflugers Arch. (2004)
 

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