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Gene Review

Actn2  -  actinin alpha 2

Mus musculus

Synonyms: 1110008F24Rik, Alpha-actinin skeletal muscle isoform 2, Alpha-actinin-2, F-actin cross-linking protein
 
 
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High impact information on Actn2

 

Biological context of Actn2

 

Anatomical context of Actn2

 

Other interactions of Actn2

  • Two nonmuscle myosin isoforms (II-B and Va), were identified as components of lipid raft fractions that also contained typical membrane skeletal proteins such as non-erythrocyte spectrins, actin, alpha-actinin-2 and tubulin subunits [9].
 

Analytical, diagnostic and therapeutic context of Actn2

References

  1. Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex. Li, H.H., Kedar, V., Zhang, C., McDonough, H., Arya, R., Wang, D.Z., Patterson, C. J. Clin. Invest. (2004) [Pubmed]
  2. Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2. Robison, A.J., Bass, M.A., Jiao, Y., MacMillan, L.B., Carmody, L.C., Bartlett, R.K., Colbran, R.J. J. Biol. Chem. (2005) [Pubmed]
  3. Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha -actinin-2, is required for myoblast fusion. Galliano, M.F., Huet, C., Frygelius, J., Polgren, A., Wewer, U.M., Engvall, E. J. Biol. Chem. (2000) [Pubmed]
  4. Down-regulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation. Huang, C., Ni, Y., Wang, T., Gao, Y., Haudenschild, C.C., Zhan, X. J. Biol. Chem. (1997) [Pubmed]
  5. Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation. Luthi-Carter, R., Apostol, B.L., Dunah, A.W., DeJohn, M.M., Farrell, L.A., Bates, G.P., Young, A.B., Standaert, D.G., Thompson, L.M., Cha, J.H. Neurobiol. Dis. (2003) [Pubmed]
  6. The enhancement of nuclear receptor transcriptional activation by a mouse actin-binding protein, alpha actinin 2. Huang, S.M., Huang, C.J., Wang, W.M., Kang, J.C., Hsu, W.C. J. Mol. Endocrinol. (2004) [Pubmed]
  7. The regeneration process of the striated urethral sphincter involves activation of intrinsic satellite cells. Yiou, R., Lefaucheur, J.P., Atala, A. Anat. Embryol. (2003) [Pubmed]
  8. Elfin is expressed during early heart development. Kotaka, M., Lau, Y.M., Cheung, K.K., Lee, S.M., Li, H.Y., Chan, W.Y., Fung, K.P., Lee, C.Y., Waye, M.M., Tsui, S.K. J. Cell. Biochem. (2001) [Pubmed]
  9. Nonmuscle myosins II-B and Va are components of detergent-resistant membrane skeletons derived from mouse forebrain. Ishmael, J.E., Safic, M., Amparan, D., Vogel, W.K., Pham, T., Marley, K., Filtz, T.M., Maier, C.S. Brain Res. (2007) [Pubmed]
 
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