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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

JMY  -  junction mediating and regulatory protein,...

Homo sapiens

Synonyms: FLJ37870, Junction-mediating and-regulatory protein
 
 
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High impact information on JMY

  • JMY and p300 associate in physiological conditions, and, during the cellular stress response, the p300/JMY complex is recruited to activated p53 [1].
  • DNA damage causes an increase in JMY protein, and, in a similar manner, small molecule inhibitors of Mdm2 activity induce JMY in unperturbed cells [2].
 

Biological context of JMY

  • The bax gene is efficiently activated by JMY, and protein isoforms that arise through alternative splicing alter the functional outcome of the p53 response [1].
 

Physical interactions of JMY

  • The results provide compelling evidence that the p300/JMY coactivator complex plays a central role in facilitating the p53 response [1].

References

  1. A novel cofactor for p300 that regulates the p53 response. Shikama, N., Lee, C.W., France, S., Delavaine, L., Lyon, J., Krstic-Demonacos, M., La Thangue, N.B. Mol. Cell (1999) [Pubmed]
  2. Mdm2 targets the p53 transcription cofactor JMY for degradation. Coutts, A.S., Boulahbel, H., Graham, A., La Thangue, N.B. EMBO Rep. (2007) [Pubmed]
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