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Gene Review

Got1  -  glutamic-oxaloacetic transaminase 1, soluble

Mus musculus

Synonyms: AI789014, Aspartate aminotransferase, cytoplasmic, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, Glutamate oxaloacetate transaminase 1, ...
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Disease relevance of Got1


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Chemical compound and disease context of Got1


Biological context of Got1


Anatomical context of Got1


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Analytical, diagnostic and therapeutic context of Got1


  1. Identification by microarray analysis of aspartate aminotransferase and glutamine synthetase as glucocorticoid target genes in a mouse Schwann cell line. Grenier, J., Tomkiewicz, C., Trousson, A., Rajkowski, K.M., Schumacher, M., Massaad, C. J. Steroid Biochem. Mol. Biol. (2005) [Pubmed]
  2. Acute, chronic and terminal toxicity to 4'-demethylepipodophyllotoxin thenylidene glucoside (VM26) in mice. Hacker, M., Roberts, D.W. Cancer Res. (1975) [Pubmed]
  3. Rat cytosolic aspartate aminotransferase: molecular cloning of cDNA and expression in Escherichia coli. Horio, Y., Tanaka, T., Taketoshi, M., Nagashima, F., Tanase, S., Morino, Y., Wada, H. J. Biochem. (1988) [Pubmed]
  4. Glutamate oxaloacetate transaminase (GOT) in the dy2J genotypes of C57BL/6J mice: possible involvement of regulatory defect in muscular dystrophy. Singh, S.M., Phillips, A., Wang, C.H. Experientia (1982) [Pubmed]
  5. Molecular cloning and sequence analysis of the human cytosolic aspartate aminotransferase gene. Choudhury, B.K., Setoyama, C., Shimada, K. Biochem. Int. (1990) [Pubmed]
  6. Chromosomal deletions around the albino locus in the mouse cause loss of hormone-inducible expression of the unlinked structural gene encoding cytosolic aspartate aminotransferase. Lia, M., Barouki, R., Waelsch, S.G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. Regulatory regions of the mitochondrial and cytosolic isoenzyme genes participating in the malate-aspartate shuttle. Setoyama, C., Ding, S.H., Choudhury, B.K., Joh, T., Takeshima, H., Tsuzuki, T., Shimada, K. J. Biol. Chem. (1990) [Pubmed]
  8. Cloning and sequence analysis of mRNA for mouse aspartate aminotransferase isoenzymes. Obaru, K., Nomiyama, H., Shimada, K., Nagashima, F., Morino, Y. J. Biol. Chem. (1986) [Pubmed]
  9. Efficacy of the potentized homeopathic drug, Carcinosin 200, fed alone and in combination with another drug, Chelidonium 200, in amelioration of p-dimethylaminoazobenzene-induced hepatocarcinogenesis in mice. Biswas, S.J., Pathak, S., Bhattacharjee, N., Das, J.K., Khuda-Bukhsh, A.R. Journal of alternative and complementary medicine (New York, N.Y.) (2005) [Pubmed]
  10. Interaction of H2-receptor antagonists, cimetidine and ranitidine with microsomal drug metabolizing and other systems in liver. Gill, M., Sanyal, S.N., Sareen, M.L. Indian J. Exp. Biol. (1991) [Pubmed]
  11. Esterase-18 (ES-18) of the house mouse (Mus musculus): biochemical characterization and genetics of an allozyme system linked to chromosome 19. von Deimling, O.H., Gaa, A., Simon, M.M. Biochem. Genet. (1988) [Pubmed]
  12. Linkage of the equine serum esterase (Es) and mitochondrial glutamate oxaloacetate transaminase (GOTM) loci. A horse-mouse homology. Andersson, L., Sandberg, K., Adalsteinsson, S., Gunnarsson, E. J. Hered. (1983) [Pubmed]
  13. Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids. Schäfer, R., Doehmer, J., Rademacher, I., Willecke, K. Somatic Cell Genet. (1980) [Pubmed]
  14. Cytosolic aspartate aminotransferase gene is a member of the glucose-regulated protein gene family in adipocytes. Plee-Gautier, E., Grimal, H., Aggerbeck, M., Barouki, R., Forest, C. Biochem. J. (1998) [Pubmed]
  15. Antiproliferative effect of pineal indoles on cultured tumor cell lines. Sze, S.F., Ng, T.B., Liu, W.K. J. Pineal Res. (1993) [Pubmed]
  16. Spontaneous glutamate release by a "fibrous"-like cerebellar astroglial cell clone. Cambier, D., Pessac, B. J. Neurochem. (1989) [Pubmed]
  17. Cysteinesulfinate metabolism. altered partitioning between transamination and decarboxylation following administration of beta-methyleneaspartate. Griffith, O.W. J. Biol. Chem. (1983) [Pubmed]
  18. Postnatal mice have low susceptibility to paracetamol toxicity. Adamson, G.M., Papadimitriou, J.M., Harman, A.W. Pediatr. Res. (1991) [Pubmed]
  19. Antidotal effectiveness of N-acetylcysteine in reversing acetaminophen-induced hepatotoxicity. Enhancement of the proteolysis of arylated proteins. Bruno, M.K., Cohen, S.D., Khairallah, E.A. Biochem. Pharmacol. (1988) [Pubmed]
  20. Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione. Tordjman, J., Leroyer, S., Chauvet, G., Quette, J., Chauvet, C., Tomkiewicz, C., Chapron, C., Barouki, R., Forest, C., Aggerbeck, M., Antoine, B. J. Biol. Chem. (2007) [Pubmed]
  21. Hepatoprotective properties of Commiphora opobalsamum ("Balessan"), a traditional medicinal plant of Saudi Arabia. Al-Howiriny, T.A., Al-Sohaibani, M.O., Al-Said, M.S., Al-Yahya, M.A., El-Tahir, K.H., Rafatullah, S. Drugs under experimental and clinical research. (2004) [Pubmed]
  22. Fenofibrate modifies transaminase gene expression via a peroxisome proliferator activated receptor alpha-dependent pathway. Edgar, A.D., Tomkiewicz, C., Costet, P., Legendre, C., Aggerbeck, M., Bouguet, J., Staels, B., Guyomard, C., Pineau, T., Barouki, R. Toxicol. Lett. (1998) [Pubmed]
  23. Developmental characteristics of trisomy 19 mice. Lorke, D.E. Acta anatomica. (1994) [Pubmed]
  24. Hepatoprotective activity of carrot (Daucus carota L.) against carbon tetrachloride intoxication in mouse liver. Bishayee, A., Sarkar, A., Chatterjee, M. Journal of ethnopharmacology. (1995) [Pubmed]
  25. Hormonal regulation of malate-aspartate shuttle enzymes during postnatal development of mice. Dey, S., Sharma, R. Indian J. Biochem. Biophys. (1998) [Pubmed]
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