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Gene Review:

Hnrnpab - heterogeneous nuclear ribonucleoprotein A/B

Mus musculus

Synonyms: 3010025C11Rik, CArG-binding factor-A, CBF-A, Cbf-a, Cgbfa, ...

Umar, A. et al., Aranburu, A. et al., Sohn, K.Y. et al., Kamada, S. et al.

Umar, Luider, Berrevoets, Grootegoed, Brinkmann,

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High impact information on Hnrpab

Using enhanced GFP (EGFP)-tagged constructs and transfection into COS7 cells, a nuclear localisation signal was defined in the C terminus of CBF-A [1].
Mitogenic stimulation of untransformed B lymphocytes promoted nuclear localisation of CBF-A [1].
We show here that CBF-A will also bind specifically to a second region in the kappa promoter that overlaps with an early B cell factor binding site [1].
Posttranslational modification of mElfin and CBF-A by androgens may be associated with a cytoskeletal change that is involved in androgen-regulated gene expression [2].
Differentially expressed proteins were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and two androgen-regulated proteins were identified as mElfin and CArG-binding factor-A (CBF-A) [2].

Biological context of Hnrpab

When the expression level of CBF-A in C2 cells increased by transfection of CBF-A expression plasmids, Sm alpha-A transcription was repressed [3].
The 90-amino-acid (aa) segment of CBF-A, which shows a high degree of sequence identity with the yeast transcription factor, HAP3, is split into exons 3 and 4 [4].
Although removal of exon 3 interrupts the CBF-A reading frame, a potential start codon at the 3' end of exon 2 is in the same reading frame as the reading frame encoding CBF-A in exons 4 to 7 [4].

References

CArG box-binding factor-A interacts with multiple motifs in immunoglobulin promoters and has a regulated subcellular distribution. Aranburu, A., Liberg, D., Honoré, B., Leanderson, T. Eur. J. Immunol. (2006) [Pubmed]
Proteomic analysis of androgen-regulated protein expression in a mouse fetal vas deferens cell line. Umar, A., Luider, T.M., Berrevoets, C.A., Grootegoed, J.A., Brinkmann, A.O. Endocrinology (2003) [Pubmed]
A protein binding to CArG box motifs and to single-stranded DNA functions as a transcriptional repressor. Kamada, S., Miwa, T. Gene (1992) [Pubmed]
Studies on the structure of the mouse CBF-A gene and properties of a truncated CBF-A isoform generated from an alternatively spliced RNA. Sohn, K.Y., Maity, S.N., de Crombrugghe, B. Gene (1994) [Pubmed]

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HNRNPAB	Bos taurus
hnrnpabb	Danio rerio
hnrnpaba	Danio rerio
HNRNPAB	Gallus gallus
HNRNPAB	Homo sapiens
HNRNPAB	Macaca mulatta
LOC100910156	Rattus norvegicus
hnrnpab	Xenopus (Silurana) tropicalis

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