Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Irs3 - insulin receptor substrate 3

Mus musculus

Synonyms: AA408304

Björnholm, M. et al., Maffucci, T. et al., Liu, S.C. et al.

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High impact information on Irs3

Insulin receptor substrate 3 is not essential for growth or glucose homeostasis [1].
Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3 [2].
Two deletions in human IRS-3 gene were identified using bioinformatics [3].
Human liver and adipose cDNA libraries were screened in an effort to clone IRS-3 cDNA [3].
The human IRS-3 gene product is predicted to lack a phosphotyrosine binding domain and also the sequence corresponding amino acid 353-407 of murine IRS-3 [3].

Biological context of Irs3

CONCLUSION/INTERPRETATION: In silico screening of the human IRS-3 genome region, combined with further biological and molecular validation, provides evidence against a functional IRS-3 in humans [3].
RESULTS: In human adipocytes we did not detect a M(r) 60 000 phosphoprotein corresponding to IRS-3, whereas in rat adipocytes IRS-3 protein and insulin-stimulated tyrosine phosphorylation was readily observed [3].

References

Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. Liu, S.C., Wang, Q., Lienhard, G.E., Keller, S.R. J. Biol. Chem. (1999) [Pubmed]
Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3. Maffucci, T., Razzini, G., Ingrosso, A., Chen, H., Iacobelli, S., Sciacchitano, S., Quon, M.J., Falasca, M. Mol. Endocrinol. (2003) [Pubmed]
Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans. Björnholm, M., He, A.R., Attersand, A., Lake, S., Liu, S.C., Lienhard, G.E., Taylor, S., Arner, P., Zierath, J.R. Diabetologia (2002) [Pubmed]

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