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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Psmc5  -  protease (prosome, macropain) 26S subunit,...

Mus musculus

Synonyms: 26S protease regulatory subunit 8, 26S proteasome AAA-ATPase subunit RPT6, Proteasome 26S subunit ATPase 5, Proteasome subunit p45, Sug1, ...
 
 
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High impact information on Psmc5

  • We discuss the possibility that mSUG1 and TIF1 may mediate the transcriptional activity of the AF-2 of nuclear receptors through different mechanisms [1].
  • In moths, the expression of the Sug1 homolog 18-56 is dramatically up-regulated during programmed cell death [2].
  • When examined, Sug1-like CAD proteins appear to function in the regulation of the 26S proteasome, as well as associate with members of the steroid/thyroid receptor superfamily and other transcriptional activators. m56 can complement the lethal phenotype of loss of SUG1 in yeast [2].
  • Overexpression of wild-type mSUG1 in ROS17/2.8 cells generated a novel proteolytic VDR fragment of approximately 50 kDa, and its production was blocked by proteasome inhibitors or by a nonhydrolyzable ATP analog [3].
  • In the present study, we demonstrate that mSUG1 (P45), a component of the 26S proteasome, interacts in a 1,25-(OH)2D3-dependent manner with the AF-2 domain of the vitamin D receptor (VDR) [3].
 

Analytical, diagnostic and therapeutic context of Psmc5

References

  1. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. vom Baur, E., Zechel, C., Heery, D., Heine, M.J., Garnier, J.M., Vivat, V., Le Douarin, B., Gronemeyer, H., Chambon, P., Losson, R. EMBO J. (1996) [Pubmed]
  2. Identification of a phylogenetically conserved Sug1 CAD family member that is differentially expressed in the mouse nervous system. Sun, D., Swaffield, J.C., Johnston, S.A., Milligan, C.E., Zoeller, R.T., Schwartz, L.M. J. Neurobiol. (1997) [Pubmed]
  3. Proteasome-mediated degradation of the vitamin D receptor (VDR) and a putative role for SUG1 interaction with the AF-2 domain of VDR. Masuyama, H., MacDonald, P.N. J. Cell. Biochem. (1998) [Pubmed]
  4. Mouse homologue of yeast Prp19 interacts with mouse SUG1, the regulatory subunit of 26S proteasome. Sihn, C.R., Cho, S.Y., Lee, J.H., Lee, T.R., Kim, S.H. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
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