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Gene Review: 

Trim27  -  tripartite motif-containing 27

Mus musculus

Synonyms: AW538890, Gm19403, Ret finger protein, Rfp, Tripartite motif-containing protein 27, ...
 
 
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High impact information on Trim27

  • The ret-finger protein gene is expressed in a variety of tumor cell lines, mouse testis and embryonic tissue, which like the mammary gland undergo periods of rapid cell division and development [1].
  • Rfp is expressed at specific stages of spermatogenesis and in various adult mouse and human tissues [2].
  • Substitution of Cys-16, Cys-31, or His-33 markedly decreased the transforming activity of Rfp/Ret [3].
  • Mapping of the Olf89 and Rfp genes to the rat genome: comparison with the mouse and human and new insights into the evolution of the rodent genome [4].
 

Associations of Trim27 with chemical compounds

  • In contrast, mutations of Cys-118 or His-124 in the second cysteine/histidine-rich motif (called B box) of Rfp/Ret did not affect its activity [3].

References

  1. Cloning and analysis of cDNA encoding bovine butyrophilin, an apical glycoprotein expressed in mammary tissue and secreted in association with the milk-fat globule membrane during lactation. Jack, L.J., Mather, I.H. J. Biol. Chem. (1990) [Pubmed]
  2. Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution. Cao, T., Borden, K.L., Freemont, P.S., Etkin, L.D. J. Cell. Sci. (1997) [Pubmed]
  3. A RING finger motif regulates transforming activity of the rfp/ret fusion gene. Hasegawa, N., Iwashita, T., Asai, N., Murakami, H., Iwata, Y., Isomura, T., Goto, H., Hayakawa, T., Takahashi, M. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  4. Mapping of the Olf89 and Rfp genes to the rat genome: comparison with the mouse and human and new insights into the evolution of the rodent genome. Szpirer, C., Szpirer, J., Rivière, M., Tazi, R., Pontarotti, P. Cytogenet. Cell Genet. (1997) [Pubmed]
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