Disease relevance of EMR1

• In 9 patients with low grade malignant lymphoma, 24% of cells were observed to possess Em receptor and antigen detectable with VIB antibody, 34-70% of cells were Em-VIB-lymphocytes and 13-54% were Em-VIB+ cells [1].

High impact information on EMR1

• Like most EGF-TM7 receptor genes, EMR4 is localized on the short arm of chromosome 19, in close proximity to EMR1 [2].
• Family members, including EMR1 and F4/80, are characterized by an extended extracellular region with several N-terminal epidermal growth factor-like (EGF) domains [3].
• The EGF-TM7 family (CD97 and EMR1) is a group of class II seven-span transmembrane receptors predominantly expressed by cells of the immune system [4].
• Southern analysis of a panel of somatic cell hybrids and fluorescence in situ hybridization have assigned the EMR1 gene to human chromosome 19p13.3 [5].
• EMR lines were able to progress through mitosis and cytokinesis at the same rate as untreated cells [6].

Biological context of EMR1

• Recent cDNA cloning of EMR1 and CD97 suggests the existence of a new group of seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19 [7].
• Fluorescent activated cell sorting analysis of the effects of EM on cell cycle traverse revealed that at EM concentrations up to 20 microM an increasing percentage of wild type cells were blocked in G2/M; no such effect occurred in EMR lines [6].

Associations of EMR1 with chemical compounds

• These EM-resistant clones (EMR 4,9,12) did not exhibit cross resistance to vinblastine, taxol, or adriamycin, and had collateral sensitivity to cytochalasin B [6].

Analytical, diagnostic and therapeutic context of EMR1

• As digital dental images become widely available, a new Electronic MR system (EMR) will be critical for the success of applying new technology to dental care [8].

References