Gene Review:
Wrn - Werner syndrome homolog (human)
Mus musculus
Synonyms:
AI846146, Exonuclease WRN, Werner syndrome ATP-dependent helicase homolog
- Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Chang, S., Multani, A.S., Cabrera, N.G., Naylor, M.L., Laud, P., Lombard, D., Pathak, S., Guarente, L., DePinho, R.A. Nat. Genet. (2004)
- Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis. Leder, A., Lebel, M., Zhou, F., Fontaine, K., Bishop, A., Leder, P. Oncogene (2002)
- In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1. Deschênes, F., Massip, L., Garand, C., Lebel, M. Hum. Mol. Genet. (2005)
- Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase. Lebel, M., Cardiff, R.D., Leder, P. Cancer Res. (2001)
- Analysis of the role of RecQ helicases in RNAi in mammals. Stein, P., Svoboda, P., Stumpo, D.J., Blackshear, P.J., Lombard, D.B., Johnson, B., Schultz, R.M. Biochem. Biophys. Res. Commun. (2002)
- Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1. Lavoie, J., Carter, R., Drouin, R., Lebel, M. Cancer Genet. Cytogenet. (2005)