The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

Kcnt1  -  potassium channel, subfamily T, member 1

Mus musculus

Synonyms: C030030G16Rik, Kiaa1422, Potassium channel subfamily T member 1, Slack, Slo2.2, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Kcnt1

  • Initial studies mapped a major determinant of virulence to the 5' end of the viral genome, which contained the 5' untranslated and the P1 regions (A. Ramsingh, A. Hixson, B. Duceman, and J. Slack, J. Virol. 64:3078-3081, 1990) [1].
  • The selection protocol included four consecutive cycles of cocultivating mutagenized cells, deficient in hypoxanthine phosphoribosyltransferase (HPRT) and wild-type cells in the presence of thioguanine (cf Slack, C, Morgan, R H M & Hooper, M L, Exp cell res 117 (1978) 195-205) [8] [2].
  • Pancreatic cells can be converted to hepatocytes by overexpression of C/EBPbeta (Shen, C-N, Slack, J.M.W. and Tosh, D., 2000. Molecular basis of transdifferentiation of pancreas to liver. Nature Cell Biology 2: 879-887) [3].
  • Hooper & Slack (1977) showed how this exchange could be detected by autoradiography as the transfer of [3H]nucleotides between PC13 (a pluripotential EC line) and PC13TG8 (a variant of PC13 which is deficient in hypoxanthine guanine phosphoribosyltransferase) [4].

References

  1. Identification of a single amino acid residue in the capsid protein VP1 of coxsackievirus B4 that determines the virulent phenotype. Caggana, M., Chan, P., Ramsingh, A. J. Virol. (1993) [Pubmed]
  2. Isolation and characterization of Chinese hamster cells defective in cell-cell coupling via gap junctions. Willecke, K., Müller, D., Drüge, P.M., Frixen, U., Schäfer, R., Dermietzel, R., Hülser, D. Exp. Cell Res. (1983) [Pubmed]
  3. C/EBPalpha and C/EBPbeta are markers of early liver development. Westmacott, A., Burke, Z.D., Oliver, G., Slack, J.M., Tosh, D. Int. J. Dev. Biol. (2006) [Pubmed]
  4. Metabolic co-operation between embryonic and embryonal carcinoma cells of the mouse. Gaunt, S.J., Papaioannou, V.E. Journal of embryology and experimental morphology. (1979) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities