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Gene Review

HIC2  -  hypermethylated in cancer 2

Homo sapiens

Synonyms: HIC1-related gene on chromosome 22 protein, HRG22, Hic-2, Hic-3, Hypermethylated in cancer 2 protein, ...
 
 
 
 
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High impact information on HIC2

  • HIC1 (hypermethylated in cancer) and its close relative HRG22 (HIC1-related gene on chromosome 22) encode transcriptional repressors with five C(2)H(2) zinc fingers and an N-terminal BTB/POZ autonomous transcriptional repression domain that is unable to recruit histone deacetylases (HDACs) [1].
 

Associations of HIC2 with chemical compounds

  • Alignment of the HIC1 and HRG22 proteins from various species highlighted a perfectly conserved GLDLSKK/R motif highly related to the consensus CtBP interaction motif (PXDLSXK/R), except for the replacement of the virtually invariant proline by a glycine [1].

References

  1. The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. Deltour, S., Pinte, S., Guerardel, C., Wasylyk, B., Leprince, D. Mol. Cell. Biol. (2002) [Pubmed]
 
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