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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DTX4  -  deltex 4, E3 ubiquitin ligase

Homo sapiens

Synonyms: Deltex4, E3 ubiquitin-protein ligase DTX4, KIAA0937, Protein deltex-4, RING finger protein 155, ...
 
 
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High impact information on DTX4

  • The cDtx2 sequence showed higher homology to KIAA0937 protein (92% identical) than to DTX1 (68% identical). cDtx2 is expressed widely in the epiblast at stage 4 [1].
 

Analytical, diagnostic and therapeutic context of DTX4

  • The cross-reactivity of the 6/50 monoclonal anti-okadaic acid antibody (mAb) to the recently discovered diarrhetic shellfish poisoning (DSP) metabolites dinophysistoxin-4 (DTX-4), dinophysistoxin-5 (DTX-5), and an okadaic acid (OA) diol ester was determined using a competitive indirect enzyme-linked immunosorbent assay (ELISA) [2].
  • These were analyzed for okadaic acid (OA), dinophysistoxin-1 (DTX-1), DTX-2, DTX-4 and diol esters by liquid chromatography coupled to mass spectrometry [3].

References

  1. The expression pattern of a novel Deltex homologue during chicken embryogenesis. Frolova, E., Beebe, D. Mech. Dev. (2000) [Pubmed]
  2. Cross-reactivity of an anti-okadaic acid antibody to dinophysistoxin-4 (DTX-4), dinophysistoxin-5 (DTX-5), and an okadaic acid diol ester. Lawrence, J.E., Cembella, A.D., Ross, N.W., Wright, J.L. Toxicon (1998) [Pubmed]
  3. Morphology, toxin composition and pigment content of Prorocentrum lima strains isolated from a coastal lagoon in southern UK. Nascimento, S.M., Purdie, D.A., Morris, S. Toxicon (2005) [Pubmed]
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