High impact information on Smc1a

• The mouse Sb1.8 gene located at the distal end of the X chromosome is subject to X inactivation [1].
• Like its human counterpart, the mouse Sb1.8 gene is X-linked, as shown by Southern blot analysis and by in situ hybridization to metaphase chromosomes [1].
• Differential association of SMC1alpha and SMC3 proteins with meiotic chromosomes in wild-type and SPO11-deficient male mice [2].
• Our results suggest that the two cohesin proteins may not always be associated in a dimer and may function as separate complexes in mammalian meiosis, with SMC1alpha playing a more specific role in synapsis [2].
• SMC1alpha and Rad21 were mainly expressed in mitotically dividing cells in the testis (somatic cells and spermatogonia), although their weak expression was detected in pre-leptotene spermatocytes [3].

Biological context of Smc1a

• At diplotene, SMC3, but not SMC1alpha, remained bound along axial elements of desynapsed chromosomes [2].

References