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Gene Review

SPDYA  -  speedy homolog A (Xenopus laevis)

Homo sapiens

 
 
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Disease relevance of SPDYA

  • An iatrogenic dissection of the left main artery with total occlusion and arrest (asystole) occurred during preoperative 4Fr coronography. "Speedy recovery" is achieved with a strategy of percutaneous primary stenting revascularization combined with cardiopulmonary maneuvers [1].
 

High impact information on SPDYA

 

Biological context of SPDYA

  • In addition to their activation via binding to cyclins, cyclin-dependent kinases (CDKs) can be activated via binding to a novel cell cycle regulator termed Speedy/Ringo, which shows no apparent similarity to cyclins [4].
  • These mammalian Speedy/Ringo proteins exhibit distinct tissue expression patterns, though all three are enriched in testis, consistent with the initial observation that Xenopus Speedy/Ringo functions during meiosis [4].
  • Human Spy1 promotes survival of mammalian cells following DNA damage [5].
  • Here we demonstrate that overexpression of human Spy1 enhances mammalian cell viability during cellular responses to DNA damage induced by genotoxic agents such as camptothecin, cisplatin, and hydroxyurea [5].
  • Here we report a role for Spy1 in apoptosis and checkpoint activation in response to UV irradiation [6].
 

Anatomical context of SPDYA

  • Speedy/Ringo A is widely expressed in tissues and cell lines [4].
  • Similar to its Xenopus counterpart, human Speedy is able to induce oocyte maturation, suggesting similar biological characteristics [3].
 

Associations of SPDYA with chemical compounds

  • In 191 (86%) procedures a fixed-wire system was used (ACE Scimed, Probe USCI, Orion Cordis), and in 30 (14%) a monorail system (Speedy Schneider, Express Scimed) [7].
 

Regulatory relationships of SPDYA

 

Other interactions of SPDYA

 

Analytical, diagnostic and therapeutic context of SPDYA

References

  1. Left main artery dissection during 4 French coronary angiography in elderly patient with severe aortic stenosis: "speedy recovery" using emergency primary stenting. Philippe, F., Bouabdallah, K., Dibie, A., Laborde, F. Journal of interventional cardiology. (2002) [Pubmed]
  2. CDK activation by non-cyclin proteins. Nebreda, A.R. Curr. Opin. Cell Biol. (2006) [Pubmed]
  3. Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2. Porter, L.A., Dellinger, R.W., Tynan, J.A., Barnes, E.A., Kong, M., Lenormand, J.L., Donoghue, D.J. J. Cell Biol. (2002) [Pubmed]
  4. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cheng, A., Xiong, W., Ferrell, J.E., Solomon, M.J. Cell Cycle (2005) [Pubmed]
  5. Human Spy1 promotes survival of mammalian cells following DNA damage. Barnes, E.A., Porter, L.A., Lenormand, J.L., Dellinger, R.W., Donoghue, D.J. Cancer Res. (2003) [Pubmed]
  6. Spy1 Expression Prevents Normal Cellular Responses to DNA Damage: INHIBITION OF APOPTOSIS AND CHECKPOINT ACTIVATION. Gastwirt, R.F., Slavin, D.A., McAndrew, C.W., Donoghue, D.J. J. Biol. Chem. (2006) [Pubmed]
  7. Percutaneous transluminal coronary angioplasty through six French catheters. Urban, P., Moles, V.P., Pande, A.K., Verine, V., Haine, E., Meier, B. The Journal of invasive cardiology. (1992) [Pubmed]
  8. Spy1 interacts with p27Kip1 to allow G1/S progression. Porter, L.A., Kong-Beltran, M., Donoghue, D.J. Mol. Biol. Cell (2003) [Pubmed]
  9. Percutaneous transradial coronary Palmaz-Schatz stent implantation, guided by intravascular ultrasound. Kiemeneij, F., Laarman, G.J., Slagboom, T. Catheterization and cardiovascular diagnosis. (1995) [Pubmed]
  10. Patient care. Speedy access. Maleske, M. Hospitals & health networks / AHA. (2004) [Pubmed]
 
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