Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

GAPVD1 - GTPase activating protein and VPS9 domains 1

Homo sapiens

Synonyms: DKFZP434C212, GAPEX5, GAPex-5, GTPase-activating protein and VPS9 domain-containing protein 1, KIAA1521, ...

Hunker, C.M. et al., Schulman, D.S. et al.

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High impact information on GAPVD1

This study is the first to show that RAP6 is a novel regulator of endocytosis that exhibits GEF activity specific for Rab5 and GAP activity specific for Ras [1].
Immunofluorescence experiments reveal that RAP6 is associated with plasma membrane and small intracellular vesicles that also contain Rab5 [1].
Verapamil caused a decrease in blood pressure (BP) and heart rate (HR) with increases in right atrial pressure (RAP 6 +/- 3-8 +/- 3, p < 0.01) and pulmonary artery wedge pressure (PAWP, 9 +/- 3-11 +/- 3 mm Hg, p < 0.01) pressures [2].

Biological context of GAPVD1

Additionally, the overexpression of RAP6 affects both fluid phase and receptor-mediated endocytosis [1].

References

Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis. Hunker, C.M., Galvis, A., Kruk, I., Giambini, H., Veisaga, M.L., Barbieri, M.A. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
Effect on verapamil on ventricular function: studies in denervated human heart. Schulman, D.S., Herman, B.A., Edwards, T., Ziady, G., Uretsky, B.F. J. Cardiovasc. Pharmacol. (1993) [Pubmed]

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