Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Map4k1 - mitogen-activated protein kinase kinase...

Mus musculus

Synonyms: HPK, Hematopoietic progenitor kinase, Hpk1, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, ...

Dürst, M. et al., Shui, J.W. et al., Schulze-Luehrmann, J. et al.

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High impact information on Map4k1

Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses [1].
Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes [2].
Two human papillomavirus type 16 (HPV 16)-immortalized human keratinocyte cell lines (HPK) were shown to have retained the ability for differentiation after subcutaneous injection into nude mice [3].

References

Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Shui, J.W., Boomer, J.S., Han, J., Xu, J., Dement, G.A., Zhou, G., Tan, T.H. Nat. Immunol. (2007) [Pubmed]
Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes. Schulze-Luehrmann, J., Santner-Nanan, B., Jha, M.K., Schimpl, A., Avots, A., Serfling, E. Blood (2002) [Pubmed]
Inverse relationship between human papillomavirus (HPV) type 16 early gene expression and cell differentiation in nude mouse epithelial cysts and tumors induced by HPV-positive human cell lines. Dürst, M., Bosch, F.X., Glitz, D., Schneider, A., zur Hausen, H. J. Virol. (1991) [Pubmed]

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