High impact information on Psg17

• The mRNAs coding for Cea4a and Cea4b exhibit the same expression kinetics during placental development as found for two other murine PSGs, Cea2 and Cea3, which contain the RGD-like motif [1].
• We have also partially characterized the Cea-2 gene and two additional ones, Cea-4 and Cea-5 [2].
• The deduced amino acid sequences of Cea-2 and Cea-6 indicate three IgV-like (N), followed by one IgC-like (A) domain (N1-N2-N3-A) [2].
• The putative promoter region of Cea-2 lacks typical TATA- or CAAT-boxes, but contains other conserved motifs that could play a role in the initiation of transcription [2].
• Another DNaseI hypersensitive site lies within or close to a simple sequence motif [(GGA)n] located in the first intron of Cea-2 [3].

Biological context of Psg17

• The genes for the pregnancy-specific glycoproteins Cea2 and Cea4, both belonging to the large carcinoembryonic antigen gene family, were localized by chromosomal in situ suppression hybridization of three YAC clones to murine chromosome 7A2-A3 [4].
• Therefore, this analysis has identified putative regulatory regions for Cea-2 and possibly CEA-related genes in general [3].

Anatomical context of Psg17

• The only Psg receptor identified is CD9, through which Psg17 induces cytokine production from macrophages cultured in vitro [5].

References