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Gene Review:

Cyb5r4 - cytochrome b5 reductase 4

Mus musculus

Synonyms: 2810034J18Rik, B5+B5R, C79736, Cb5cb5r, Cytochrome b5 reductase 4, ...

Xie, J. et al., Larade, K. et al., Andersen, G. et al.

Andersen, Wegner, Rose, Xie, Zhu, Larade, Johansen, Ek, Lauenborg, Drivsholm, Borch-Johnsen, Damm, Hansen, Bunn, Pedersen,

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High impact information on Cyb5r4

At 4 weeks of age, Ncb5or-/- mice have normal blood glucose levels but impaired glucose tolerance [1].
Isolated Ncb5or-/- islets have markedly impaired glucose- or arginine-stimulated insulin secretion [1].
Four-week-old Ncb5or-/- mice have enhanced sensitivity to the diabetogenic agent streptozotocin [1].
Recent data show that homozygous Ncb5or(-/-) knock-out mice present with an early-onset nonautoimmune diabetes phenotype [2].
Promoter characterization and transcriptional regulation of Ncb5or, a novel reductase necessary for pancreatic beta-cell maintenance [3].

References

Absence of a reductase, NCB5OR, causes insulin-deficient diabetes. Xie, J., Zhu, H., Larade, K., Ladoux, A., Seguritan, A., Chu, M., Ito, S., Bronson, R.T., Leiter, E.H., Zhang, C.Y., Rosen, E.D., Bunn, H.F. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus. Andersen, G., Wegner, L., Rose, C.S., Xie, J., Zhu, H., Larade, K., Johansen, A., Ek, J., Lauenborg, J., Drivsholm, T., Borch-Johnsen, K., Damm, P., Hansen, T., Bunn, H.F., Pedersen, O. Diabetes (2004) [Pubmed]
Promoter characterization and transcriptional regulation of Ncb5or, a novel reductase necessary for pancreatic beta-cell maintenance. Larade, K., Bunn, H.F. Biochim. Biophys. Acta (2006) [Pubmed]

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