The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

TPK1  -  thiamin pyrophosphokinase 1

Homo sapiens

Synonyms: HTPK1, PP20, Placental protein 20, THMD5, Thiamin pyrophosphokinase 1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TPK1

 

High impact information on TPK1

 

Biological context of TPK1

 

Anatomical context of TPK1

 

Associations of TPK1 with chemical compounds

  • The availability of the human TPK1 gene will provide another useful tool for studying the role of this enzyme in human thiamin metabolism and deficiency state [8].
  • Pyrithiamine as a substrate for thiamine pyrophosphokinase [5].
  • The kinetic properties of human thiamin pyrophosphokinase (hTPK1) were investigated using purified histidine-tagged recombinant protein [11].
  • These findings are consistent with the views that TMP is not directly converted to TPP but after being dephosphorylated by the action of a monoesterase, thiamine is pyrophosphorylated with ATP by thiamine pyrophosphokinase (EC 2.7.6.2) to form TPP and thus give a clear evidence regarding the mechanism of TPP formation in plant tissues [12].
 

Other interactions of TPK1

  • Isolation and characterization of four new placental tissue proteins (PP18, PP19, PP20, PP21) [9].
 

Analytical, diagnostic and therapeutic context of TPK1

References

  1. Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK). Bellyei, S., Szigeti, A., Boronkai, A., Szabo, Z., Bene, J., Janaky, T., Barna, L., Sipos, K., Minik, O., Kravjak, A., Ohmacht, R., Melegh, B., Zavodszky, P., Than, G.N., Sumegi, B., Bohn, H., Than, N.G. Placenta (2005) [Pubmed]
  2. Isolation and characterization of a human thiamine pyrophosphokinase cDNA. Nosaka, K., Onozuka, M., Kakazu, N., Hibi, S., Nishimura, H., Nishino, H., Abe, T. Biochim. Biophys. Acta (2001) [Pubmed]
  3. Thiamine-responsive megaloblastic anemia with diabetes mellitus and sensorineural deafness. Akinci, A., Teziç, T., Ertürk, G., Tarim, O., Dalva, K. Acta paediatrica Japonica; Overseas edition. (1993) [Pubmed]
  4. A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype. Pritchard, L., Sloane-Stanley, J.A., Sharpe, J.A., Aspinwall, R., Lu, W., Buckle, V., Strmecki, L., Walker, D., Ward, C.J., Alpers, C.E., Zhou, J., Wood, W.G., Harris, P.C. Hum. Mol. Genet. (2000) [Pubmed]
  5. Pyrithiamine as a substrate for thiamine pyrophosphokinase. Liu, J.Y., Timm, D.E., Hurley, T.D. J. Biol. Chem. (2006) [Pubmed]
  6. De novo t(7;10)(q33;q23) translocation and closely juxtaposed microdeletion in a patient with macrocephaly and developmental delay. Yue, Y., Grossmann, B., Holder, S.E., Haaf, T. Hum. Genet. (2005) [Pubmed]
  7. Molecular cloning and analysis of the 5'-flanking region of the human thiamin pyrophosphokinase gene. Onozuka, M., Konno, H., Akaji, K., Nishino, H., Nosaka, K. J. Nutr. Sci. Vitaminol. (2005) [Pubmed]
  8. Molecular cloning of human thiamin pyrophosphokinase. Zhao, R., Gao, F., Goldman, I.D. Biochim. Biophys. Acta (2001) [Pubmed]
  9. Isolation and characterization of four new placental tissue proteins (PP18, PP19, PP20, PP21). Bohn, H., Winckler, W. Arch. Gynecol. (1985) [Pubmed]
  10. Thiamine-responsive anemia in DIDMOAD syndrome. Borgna-Pignatti, C., Marradi, P., Pinelli, L., Monetti, N., Patrini, C. J. Pediatr. (1989) [Pubmed]
  11. Steady-state kinetics and mutational studies of recombinant human thiamin pyrophosphokinase. Onozuka, M., Nosaka, K. J. Nutr. Sci. Vitaminol. (2003) [Pubmed]
  12. Purification and properties of thiamine pyrophosphokinase from parsely leaf. Mitsuda, H., Takii, Y., Iwami, K., Yasumoto, K. J. Nutr. Sci. Vitaminol. (1975) [Pubmed]
  13. The immunocytochemical localization of new soluble placental tissue proteins (PP14, 16, 17, 19, 20 and PP21) in human and cynomolgus monkey placentae. Inaba, N., Sato, N., Fukazawa, I., Ota, Y., Shirotake, S., Takamizawa, H., Nozawa, S., Bohn, H. Arch. Gynecol. (1987) [Pubmed]
 
WikiGenes - Universities