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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SESN1  -  sestrin 1

Homo sapiens

Synonyms: PA26, SEST1, Sestrin-1, p53-regulated protein PA26
 
 
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Disease relevance of SESN1

 

High impact information on SESN1

  • The structures and associated biochemical assays reveal the mechanism of binding, which involves an interaction between the PA26 C terminus and a conserved lysine [2].
  • PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes [3].
  • In this study we identified a novel gene, PA26, which maps to chromosome 6q21 and encodes at least three transcript isoforms, of which two are differentially induced by genotoxic stress (UV, gamma-irradiation and cytotoxic drugs) in a p53-dependent manner [3].
  • Immunological analysis suggests that PA26 protein(s) is localized to the cell nucleus [3].
  • During early embryogenesis of Xenopus, the orthologue of PA26, XPA26 is exclusively expressed in the notochord, a midline structure [4].
 

Associations of SESN1 with chemical compounds

  • We have searched for millimetre-wave line emission from ethylene oxide (c-C2H4O) and its structural isomer acetaldehyde (CH3CHO) in 11 molecular clouds using SEST [5].
 

Analytical, diagnostic and therapeutic context of SESN1

  • No clues to its functions were revealed by sequence analysis, although pronounced negative regulation by serum factors argues for a potential role of PA26 in growth regulation [3].

References

  1. Identifying illness parameters in fatiguing syndromes using classical projection methods. Broderick, G., Craddock, R.C., Whistler, T., Taylor, R., Klimas, N., Unger, E.R. Pharmacogenomics (2006) [Pubmed]
  2. The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions. Förster, A., Masters, E.I., Whitby, F.G., Robinson, H., Hill, C.P. Mol. Cell (2005) [Pubmed]
  3. PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes. Velasco-Miguel, S., Buckbinder, L., Jean, P., Gelbert, L., Talbott, R., Laidlaw, J., Seizinger, B., Kley, N. Oncogene (1999) [Pubmed]
  4. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. Peeters, H., Debeer, P., Bairoch, A., Wilquet, V., Huysmans, C., Parthoens, E., Fryns, J.P., Gewillig, M., Nakamura, Y., Niikawa, N., Van de Ven, W., Devriendt, K. Hum. Genet. (2003) [Pubmed]
  5. Abundances of ethylene oxide and acetaldehyde in hot molecular cloud cores. Nummelin, A., Dickens, J.E., Bergman, P., Hjalmarson, A., Irvine, W.M., Ikeda, M., Ohishi, M. Astronomy and astrophysics. (1998) [Pubmed]
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