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5-HT1A  -  5-hydroxytryptamine (serotonin) receptor 1A

Drosophila melanogaster

Synonyms: 5-HT receptor 2A, 5-HT-dro2A, 5-HT1ADro, 5-HT[1A]Dro, 5-HT[[1ADro]], ...
 
 
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High impact information on 5-HT1A

 

Biological context of 5-HT1A

  • The first 88 amino acids of the 5HT receptor, isolated by a 5HT-affinity column followed by anion exchange chromatography and C3 reverse-phase HPLC exhibited a 43% sequence homology with Lymnaea stagnalis 5HT-receptor [5].
  • At the Drosophila NMJ, MDMA altered synaptic transmission but not through a 5-HT receptor [6].

References

  1. A family of Drosophila serotonin receptors with distinct intracellular signalling properties and expression patterns. Saudou, F., Boschert, U., Amlaiky, N., Plassat, J.L., Hen, R. EMBO J. (1992) [Pubmed]
  2. Statistical parametric mapping of 5-HT1A receptor binding in temporal lobe epilepsy with hippocampal ictal onset on intracranial EEG. Merlet, I., Ryvlin, P., Costes, N., Dufournel, D., Isnard, J., Faillenot, I., Ostrowsky, K., Lavenne, F., Le Bars, D., Mauguière, F. Neuroimage (2004) [Pubmed]
  3. Effects of population structure and sex on association between serotonin receptors and Drosophila heart rate. Nikoh, N., Duty, A., Gibson, G. Genetics (2004) [Pubmed]
  4. Molecular cloning and functional expression of a serotonin receptor from the Southern cattle tick, Boophilus microplus (Acari: Ixodidae). Chen, A., Holmes, S.P., Pietrantonio, P.V. Insect Mol. Biol. (2004) [Pubmed]
  5. Putative leech dopamine1-like receptor molecular characterization: sequence homologies between dopamine and serotonin leech CNS receptors explain pharmacological cross-reactivities. Salzet, B., Stefano, G.B., Verger-Bocquet, M., Salzet, M. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  6. Actions of MDMA at glutamatergic neuromuscular junctions. Sparks, G.M., Dasari, S., Cooper, R.L. Neurosci. Res. (2004) [Pubmed]
 
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