Disease relevance of B3GNT8

• This novel beta3Gn-T was cloned from a human colon cancer cell line and named beta3Gn-T8 based on its position in a phylogenetic tree and enzymatic activity [1].
• In most of the colorectal cancer tissues examined, the level of beta3Gn-T8 transcript was significantly higher than in normal tissue [1].

High impact information on B3GNT8

• These results indicated that beta3Gn-T8 is involved in the biosynthesis of poly-N-acetyllactosamine chains on tetraantennary (beta1,6-branched) N-glycan [1].
• Beta3Gn-T8 transfers GlcNAc to the non-reducing terminus of the Galbeta1-4GlcNAc of tetraantennary N-glycan in vitro [1].
• Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family [2].
• B3GALT7 is mapped to chromosome 19q13.2 by browsing the UCSC genomic database [2].
• In addition, it was also demonstrated that B3GALT7 is differentially transcribed in human tumor cell lines [2].

Chemical compound and disease context of B3GNT8

• A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer [1].

Anatomical context of B3GNT8

• Northern blotting showed that B3GALT7 was highly expressed in lung, throat and ileum, whereas the expression level was low in tongue, breast, uteri, testis [2].

References