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Gene Review

Unc13a  -  unc-13 homolog A (C. elegans)

Mus musculus

Synonyms: 2410078G03Rik, Munc13-1, Protein unc-13 homolog A
 
 
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High impact information on Unc13a

  • We examined genetically defined and functionally unique axonal subpopulations of synapses in excitatory hippocampal neurons that utilize either Munc13-1 or Munc13-2 as synaptic vesicle priming factor [1].
  • Moreover, the levels of Munc13-1 and ubMunc13-2 levels are decreased in RIM1alpha-deficient brain, and Munc13-1 is not properly enriched at active zones of mossy fiber terminals of the mouse hippocampus if RIM1alpha is absent [2].
  • We identify a single point mutation in Munc13-1 and ubMunc13-2 (I121N) that, depending on the type of assay used, strongly perturbs or abolishes RIM1alpha binding in vitro and in cultured fibroblasts, and we demonstrate that RIM1alpha binding-deficient ubMunc13-2(I121) is not efficiently recruited to synapses [2].
  • To understand the mechanism of C1 domain-mediated modulation of Munc13 function, we examined how PDBu increases neurotransmitter release [3].
  • Deletion of Munc13-1/unc13 causes total arrest of synaptic transmission due to a complete loss of fusion-competent synaptic vesicles [4].
 

Associations of Unc13a with chemical compounds

 

Biological context of Unc13a

  • We show here that the active zone recruitment of Munc13 isoforms Munc13-1 and ubMunc13-2 is regulated by their binding to the Rab3A-interacting molecule RIM1alpha, a key determinant of long term potentiation of synaptic transmission at mossy fiber synapses in the hippocampus [2].
  • The GA search demonstrates that the parameters that control the kinetics of exocytosis are the rate constants of the steps downstream to synaptotagmin binding, and that the equilibrium constant of the binding of calcium to Munc13 controls the calcium-dependent priming process [6].
 

Anatomical context of Unc13a

 

Other interactions of Unc13a

References

  1. Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Rosenmund, C., Sigler, A., Augustin, I., Reim, K., Brose, N., Rhee, J.S. Neuron (2002) [Pubmed]
  2. Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2. Andrews-Zwilling, Y.S., Kawabe, H., Reim, K., Varoqueaux, F., Brose, N. J. Biol. Chem. (2006) [Pubmed]
  3. Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion. Basu, J., Betz, A., Brose, N., Rosenmund, C. J. Neurosci. (2007) [Pubmed]
  4. Munc13-1 is required for the sustained release of insulin from pancreatic beta cells. Kang, L., He, Z., Xu, P., Fan, J., Betz, A., Brose, N., Xu, T. Cell metabolism. (2006) [Pubmed]
  5. Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Kwan, E.P., Xie, L., Sheu, L., Nolan, C.J., Prentki, M., Betz, A., Brose, N., Gaisano, H.Y. Diabetes (2006) [Pubmed]
  6. Systematic search for the rate constants that control the exocytotic process from chromaffin cells by a genetic algorithm. Mezer, A., Ashery, U., Gutman, M., Project, E., Bosis, E., Fibich, G., Nachliel, E. Biochim. Biophys. Acta (2006) [Pubmed]
  7. The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice. Augustin, I., Korte, S., Rickmann, M., Kretzschmar, H.A., Südhof, T.C., Herms, J.W., Brose, N. J. Neurosci. (2001) [Pubmed]
 
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