The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

KRT6B  -  keratin 6B, type II

Homo sapiens

Synonyms: CK-6B, CK6B, Cytokeratin-6B, K6B, KRTL1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of KRT6B

 

High impact information on KRT6B

  • Those with the rarer Jackson-Lawler Syndrome (MIM #167210; PC-2) lack oral involvement but have natal teeth and cutaneous cysts [3].
  • These results reveal the hitherto unknown role of the K6b isoform in epithelial biology, as well as genetic heterogeneity in PC-2 [4].
  • Our results show that the proinflammatory (TNFalpha) and the proliferative (EGF) signals in epidermis separately and independently regulate the expression of the same K6b keratin isoform [5].
  • Inflammatory versus proliferative processes in epidermis. Tumor necrosis factor alpha induces K6b keratin synthesis through a transcriptional complex containing NFkappa B and C/EBPbeta [5].
  • It has been demonstrated that PC-2 is associated with germline mutations in the keratin 17 (K17) gene and in its expression partner keratin 6b [6].
 

Biological context of KRT6B

 

Anatomical context of KRT6B

 

Associations of KRT6B with chemical compounds

  • These conditions trigger the synthesis of phytochelatins (PCs), glutathione-derived metal-binding peptides, shown here as PC2 accumulation [8].
 

Other interactions of KRT6B

 

Analytical, diagnostic and therapeutic context of KRT6B

  • No significant difference between PC2 values of the MG and control groups was observed (p>0.05) [9].
  • PC2 antiserum gave a specific immunoprecipitation of type 2 activity from insulin granule extracts [2].

References

  1. Keratin 17 mutation in pachyonychia congenita type 2 with early onset sebaceous cysts. Feng, Y.G., Xiao, S.X., Ren, X.R., Wang, W.Q., Liu, A., Pan, M. Br. J. Dermatol. (2003) [Pubmed]
  2. Proprotein-processing endopeptidases of the insulin secretory granule. Bailyes, E.M., Bennett, D.L., Hutton, J.C. Enzyme (1991) [Pubmed]
  3. Mutation of a type II keratin gene (K6a) in pachyonychia congenita. Bowden, P.E., Haley, J.L., Kansky, A., Rothnagel, J.A., Jones, D.O., Turner, R.J. Nat. Genet. (1995) [Pubmed]
  4. A mutation in human keratin K6b produces a phenocopy of the K17 disorder pachyonychia congenita type 2. Smith, F.J., Jonkman, M.F., van Goor, H., Coleman, C.M., Covello, S.P., Uitto, J., McLean, W.H. Hum. Mol. Genet. (1998) [Pubmed]
  5. Inflammatory versus proliferative processes in epidermis. Tumor necrosis factor alpha induces K6b keratin synthesis through a transcriptional complex containing NFkappa B and C/EBPbeta. Komine, M., Rao, L.S., Kaneko, T., Tomic-Canic, M., Tamaki, K., Freedberg, I.M., Blumenberg, M. J. Biol. Chem. (2000) [Pubmed]
  6. Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2. Celebi, J.T., Tanzi, E.L., Yao, Y.J., Michael, E.J., Peacocke, M. J. Invest. Dermatol. (1999) [Pubmed]
  7. Up-regulated gene expression in the conjunctival epithelium of patients with Sjögren's syndrome. Kawasaki, S., Kawamoto, S., Yokoi, N., Connon, C., Minesaki, Y., Kinoshita, S., Okubo, K. Exp. Eye Res. (2003) [Pubmed]
  8. Proteome changes in Arabidopsis thaliana roots upon exposure to Cd2+. Roth, U., von Roepenack-Lahaye, E., Clemens, S. J. Exp. Bot. (2006) [Pubmed]
  9. Interpretation of the repetitive nerve stimulation test results using principal component analysis. Cengiz, B., Kuruoğlu, H.R. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2006) [Pubmed]
 
WikiGenes - Universities