Gene Review:
TLR15 - toll-like receptor 15
Gallus gallus
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Disease relevance of TLR15
- Following in vivo Salmonella enterica serovar Typhimurium infection, quantitative real-time PCR demonstrated significant upregulation of TLR15 in the cecum of infected chickens [1].
High impact information on TLR15
- In vitro studies revealed TLR15 upregulation in chicken embryonic fibroblasts stimulated with heat-killed S. enterica serovar Typhimurium [1].
- The gene for TLR15 was sequenced and is found on chromosome 3, and it has archetypal TIR and transmembrane domains and a distinctive arrangement of extracellular leucine-rich regions. mRNA for TLR15 was detected in the spleen, bursa, and bone marrow of healthy chickens, suggesting a role for this novel receptor in constitutive host defense [1].
- We have identified a novel TLR, TLR15, by bioinformatic analysis of the chicken genome, which is distinct from any known vertebrate TLR and thus appears to be avian specific [1].
References
- Induction of a novel chicken Toll-like receptor following Salmonella enterica serovar Typhimurium infection. Higgs, R., Cormican, P., Cahalane, S., Allan, B., Lloyd, A.T., Meade, K., James, T., Lynn, D.J., Babiuk, L.A., O'farrelly, C. Infect. Immun. (2006) [Pubmed]
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