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Gene Review: 

CAPRIN1  -  cell cycle associated protein 1

Gallus gallus

Synonyms: GPIAP1, M11S1, caprin-1
 
 
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High impact information on CAPRIN1

  • Absence of caprin-1 results in defects in cellular proliferation [1].
  • We disrupted caprin-1 alleles in the chicken B lymphocyte line DT40 using homologous recombination [1].
  • Suppression of expression of human Caprin-1 resulted in slowing of the proliferation rate, due to prolongation of the G1 phase of the cell cycle, formally demonstrating that Caprin-1 was essential for normal cellular proliferation [1].
  • RT6 is an enzymatically active GPI-anchored membrane protein that was originally discovered in the rat as a peripheral T cell alloantigen [2].
  • DRAGON shares high sequence homology with two other GPI-anchored membrane proteins: the mouse ortholog of chick repulsive guidance molecule (mRGM), which is expressed in the mouse nervous system in areas complementary to DRAGON, and DRAGON-like muscle (DL-M), the expression of which is restricted to skeletal and cardiac muscle [3].

References

  1. Absence of caprin-1 results in defects in cellular proliferation. Wang, B., David, M.D., Schrader, J.W. J. Immunol. (2005) [Pubmed]
  2. Molecular characterization of mouse T-cell ecto-ADP-ribosyltransferase Rt6: cloning of a second functional gene and identification of the Rt6 gene products. Hollmann, C., Haag, F., Schlott, M., Damaske, A., Bertuleit, H., Matthes, M., Kühl, M., Thiele, H.G., Koch-Nolte, F. Mol. Immunol. (1996) [Pubmed]
  3. DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. Samad, T.A., Srinivasan, A., Karchewski, L.A., Jeong, S.J., Campagna, J.A., Ji, R.R., Fabrizio, D.A., Zhang, Y., Lin, H.Y., Bell, E., Woolf, C.J. J. Neurosci. (2004) [Pubmed]
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