Gene Review:
NDUFA1 - NADH dehydrogenase (ubiquinone) 1 alpha...
Homo sapiens
Synonyms:
CI-MWFE, Complex I-MWFE, MWFE, NADH-ubiquinone oxidoreductase MWFE subunit, ZNF183
- Downregulation of NDUFA1 and other oxidative phosphorylation-related genes is a consistent feature of basal cell carcinoma. Mamelak, A.J., Kowalski, J., Murphy, K., Yadava, N., Zahurak, M., Kouba, D.J., Howell, B.G., Tzu, J., Cummins, D.L., Liégeois, N.J., Berg, K., Sauder, D.N. Exp. Dermatol. (2005)
- NDUFA-1 is not a nuclear modifier gene in Leber hereditary optic neuropathy. Man, P.Y., Brown, D.T., Wehnert, M.S., Zeviani, M., Carrara, F., Turnbull, D.M., Chinnery, P.F. Neurology (2002)
- X-linked NDUFA1 gene mutations associated with mitochondrial encephalomyopathy. Fernandez-Moreira, D., Ugalde, C., Smeets, R., Rodenburg, R.J., Lopez-Laso, E., Ruiz-Falco, M.L., Briones, P., Martin, M.A., Smeitink, J.A., Arenas, J. Ann. Neurol. (2007)
- Suppression of complex I gene expression induces optic neuropathy. Qi, X., Lewin, A.S., Hauswirth, W.W., Guy, J. Ann. Neurol. (2003)
- The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria. Au, H.C., Seo, B.B., Matsuno-Yagi, A., Yagi, T., Scheffler, I.E. Proc. Natl. Acad. Sci. U.S.A. (1999)
- SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I. Qi, X., Lewin, A.S., Sun, L., Hauswirth, W.W., Guy, J. Ann. Neurol. (2004)
- Development and characterization of a conditional mitochondrial complex I assembly system. Yadava, N., Houchens, T., Potluri, P., Scheffler, I.E. J. Biol. Chem. (2004)
- Isolation, mapping, and genomic structure of an X-linked gene for a subunit of human mitochondrial complex I. Zhuchenko, O., Wehnert, M., Bailey, J., Sun, Z.S., Lee, C.C. Genomics (1996)
- Adaptive selection of mitochondrial complex I subunits during primate radiation. Mishmar, D., Ruiz-Pesini, E., Mondragon-Palomino, M., Procaccio, V., Gaut, B., Wallace, D.C. Gene (2006)
- Sequence variations in the NDUFA1 gene encoding a subunit of complex I of the respiratory chain. Wittig, I., Augstein, P., Brown, G.K., Fujii, T., Rötig, A., Rustin, P., Munnich, A., Seibel, P., Thorburn, D., Wissinger, B., Tamboom, K., Metspalu, A., Lamantea, E., Zeviani, M., Wehnert, M.S. J. Inherit. Metab. Dis. (2001)
- Mass spectrometric identification of a novel phosphorylation site in subunit NDUFA10 of bovine mitochondrial complex I. Schilling, B., Aggeler, R., Schulenberg, B., Murray, J., Row, R.H., Capaldi, R.A., Gibson, B.W. FEBS Lett. (2005)
- Import and orientation of the MWFE protein in mitochondrial NADH-ubiquinone oxidoreductase. Yadava, N., Scheffler, I.E. Mitochondrion (2004)
- Molecular genetics of complex I-deficient Chinese hamster cell lines. Scheffler, I.E., Yadava, N., Potluri, P. Biochim. Biophys. Acta (2004)