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Gene Review

Lrrc6  -  leucine rich repeat containing 6 (testis)

Mus musculus

Synonyms: LRTP, Leucine-rich repeat-containing protein 6, Leucine-rich testis-specific protein, Lrtp, Mc2, ...
 
 
 
 
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High impact information on Lrrc6

  • The transient upregulation of Mc2 mRNA in osteoblast-like cells and its interesting inverse regulation to osteocalcin suggest an important role in osteoblastic differentiation [1].
  • Using differential display of mRNA from subconfluent and confluent MC3T3-E1 cultures, we isolated and cloned a novel cDNA transcript, named Mc2, exhibiting an open reading frame of 162 bp and without extensive homologies to sequences in the EMBL database [1].
  • The presence of the Mc2 mRNA was verified in primary mouse osteoblasts [1].
  • Treatment of these cells with by 3,3',5-triiodo-l-thyronine resulted in an inhibition of the culture time-dependent upregulation of Mc2 mRNA, whereby osteocalcin mRNA was highly expressed [1].
  • This inverse regulation of Mc2 and osteocalcin mRNAs was also found in ROS 17/2.8 cells and in mouse bone marrow stromal cells [1].
 

Analytical, diagnostic and therapeutic context of Lrrc6

  • Mc2 mRNA was upregulated during the transition of MC3T3-E1 cell cultures from subconfluence to confluence [1].

References

 
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