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Gene Review

CYP2W1  -  cytochrome P450, family 2, subfamily W,...

Homo sapiens

Synonyms: CYPIIW1, Cytochrome P450 2W1, FLJ20359, MGC34287
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Disease relevance of CYP2W1

  • The level of expression of human cytochrome P450 2W1 achieved using codon optimization for E. coli was 1800 nmol of cytochrome P450 per liter of culture, the highest level achieved in this laboratory to date [1].

High impact information on CYP2W1


Biological context of CYP2W1

  • The human genome project revealed a new member of the P450 family 2, CYP2W1, which has orthologous form in other vertebrate species, suggesting CYP2W1's significant physiological function [3].

Associations of CYP2W1 with chemical compounds


Other interactions of CYP2W1

  • In the bicistronic expression system for human CYP2W1 and NADPH-P450 reductase, the formation of blue pigment, indigo, was observed in bacterial cultures [3].

Analytical, diagnostic and therapeutic context of CYP2W1


  1. Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Wu, Z.L., Sohl, C.D., Shimada, T., Guengerich, F.P. Mol. Pharmacol. (2006) [Pubmed]
  2. Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1. Karlgren, M., Gomez, A., Stark, K., Svärd, J., Rodriguez-Antona, C., Oliw, E., Bernal, M.L., Ramón y Cajal, S., Johansson, I., Ingelman-Sundberg, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  3. Enzymatic properties of human CYP2W1 expressed in Escherichia coli. Yoshioka, H., Kasai, N., Ikushiro, S., Shinkyo, R., Kamakura, M., Ohta, M., Inouye, K., Sakaki, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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