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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nap1l5  -  nucleosome assembly protein 1-like 5

Mus musculus

Synonyms: 1110020M21Rik, MNCb-0385, Nucleosome assembly protein 1-like 5
 
 
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High impact information on Nap1l5

  • Nap1l5 is located on proximal chromosome 6 and encodes a protein with homology with nucleosome assembly proteins (NAPs); it has tissue-specific imprinting with expression from the paternal allele [1].
  • Nap1l5 expression was localised mainly to the adrenal medulla, whilst Peg13 expression was observed more generally throughout the adrenal medulla and the outer cortical layers [2].
  • FISH has mapped Nap1l5 to G-band 6C1, within the sub-proximal imprinting region but several G-bands distal to the Peg1/Mest cluster [3].
  • A reassessment of imprinting regions and phenotypes on mouse chromosome 6: Nap1l5 locates within the currently defined sub-proximal imprinting region [3].
  • The detailed expression profiles of Nap1l5 and Peg13 were generally similar with widespread expression that was relatively high in the septal and hypothalamic regions, the hippocampus and the cerebral cortex [2].

References

  1. Identification of novel imprinted genes in a genome-wide screen for maternal methylation. Smith, R.J., Dean, W., Konfortova, G., Kelsey, G. Genome Res. (2003) [Pubmed]
  2. Expression patterns of the novel imprinted genes Nap1l5 and Peg13 and their non-imprinted host genes in the adult mouse brain. Davies, W., Smith, R.J., Kelsey, G., Wilkinson, L.S. Gene Expr. Patterns (2004) [Pubmed]
  3. A reassessment of imprinting regions and phenotypes on mouse chromosome 6: Nap1l5 locates within the currently defined sub-proximal imprinting region. Beechey, C.V. Cytogenet. Genome Res. (2004) [Pubmed]
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